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[Study on transdermal characteristics of compound Nanxing pain-relieving cataplasm and effects of gaultherolin in prescriptions].

AbstractOBJECTIVE:
To study transdermal absorption characteristics of eugenol in compound Nanxing pain-relieving cataplasm, and discuss the effect of gaultherolin on the transdermal absorption of the cataplasm.
METHOD:
The improved franz diffusing cell was adopted with hairless mice skins as transdermal carriers. The content of eugenol in receptor liquid, skins and cataplasm were analyzed by HPLC and compared with the cataplasm without gaultherolin.
RESULT:
The penetration rates of eugenol of cataplasms with and without gaultherolin were 13.18 and 9.58 microg x cm(-2) x h(-1), with the retention amount in skins of (185.02 +/- 19.23) and (160.23 +/- 16.54) microg x g(-1) and the retention amount in cataplasms was (1.96 +/- 0.12) and (1.71 +/- 0.15) mg, respectively.
CONCLUSION:
Eugenol in compound Nanxing pain-relieving cataplasm has good pereutaoeous permeation. Gaultherolin in the cataplasm prescription can promote the absorption of eugenol.
AuthorsYing Li, Shou-Ying Du, Yang Lu, Jie Bai, Ying-Zi Wang, Yue Wang, Yu-Shu Xing, Wei Xiao
JournalZhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 38 Issue 16 Pg. 2601-4 (Aug 2013) ISSN: 1001-5302 [Print] China
PMID24228571 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Analgesics
  • Drugs, Chinese Herbal
  • Salicylates
  • nanxing
  • methyl salicylate
Topics
  • Analgesics (chemistry, metabolism, therapeutic use)
  • Animals
  • Chemistry, Pharmaceutical (methods)
  • Drugs, Chinese Herbal (chemistry, metabolism, therapeutic use)
  • Mice
  • Pain (drug therapy)
  • Salicylates (chemistry)
  • Skin (metabolism)
  • Skin Absorption
  • Time Factors

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