Abstract | BACKGROUND: MATERIALS AND METHODS: The pharmacokinetic and biodistribution of BA in N1S1 tumor-bearing rats were analyzed. Rats were injected with 25 mg B/kg body weight via tail veins before neutron irradiation at the Tsing Hua Open-pool Reactor, and the efficacy of BNCT was evaluated from the tumor size, tumor blood flow, and biochemical analyses. RESULTS: HCC-bearing rats administered BNCT showed reductions in tumor size on ultrasound imaging, as well as an obvious reduction in the distribution of tumor blood flow. The lesion located in livers had disappeared on the 80th day after BNCT; a recovery of values to normal levels was also recorded. CONCLUSION: BA-mediated BNCT is a promising alternative for liver cancer therapy since the present study demonstrated the feasibility of curing a liver tumor and restoring liver function in rats. Efforts are underway to investigate the histopathological features and the detailed mechanisms of BA-mediated BNCT.
|
Authors | Sy-Yu Lin, Chen-Jou Lin, Jiunn-Wang Liao, Jinn-Jer Peir, Wei-Lin Chen, Chin-Wen Chi, Yung-Chang Lin, Yu-Ming Liu, Fong-In Chou |
Journal | Anticancer research
(Anticancer Res)
Vol. 33
Issue 11
Pg. 4799-809
(Nov 2013)
ISSN: 1791-7530 [Electronic] Greece |
PMID | 24222116
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Boric Acids
- Boron
- boric acid
|
Topics |
- Animals
- Boric Acids
(metabolism)
- Boron
(pharmacokinetics)
- Boron Neutron Capture Therapy
- Carcinoma, Hepatocellular
(metabolism, pathology, radiotherapy)
- Disease Models, Animal
- Liver
(metabolism, radiation effects)
- Liver Neoplasms
(metabolism, pathology, radiotherapy)
- Male
- Rats
- Rats, Sprague-Dawley
- Tissue Distribution
|