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An animal model of MERS produced by infection of rhesus macaques with MERS coronavirus.

Abstract
In 2012, a novel coronavirus (CoV) associated with severe respiratory disease, Middle East respiratory syndrome (MERS-CoV; previously known as human coronavirus-Erasmus Medical Center or hCoV-EMC), emerged in the Arabian Peninsula. To date, 114 human cases of MERS-CoV have been reported, with 54 fatalities. Animal models for MERS-CoV infection of humans are needed to elucidate MERS pathogenesis and to develop vaccines and antivirals. In this study, we developed rhesus macaques as a model for MERS-CoV using intratracheal inoculation. The infected monkeys showed clinical signs of disease, virus replication, histological lesions, and neutralizing antibody production, indicating that this monkey model is suitable for studies of MERS-CoV infection.
AuthorsYanfeng Yao, Linlin Bao, Wei Deng, Lili Xu, Fengdi Li, Qi Lv, Pin Yu, Ting Chen, Yanfeng Xu, Hua Zhu, Jing Yuan, Songzhi Gu, Qiang Wei, Honglin Chen, Kwok-Yung Yuen, Chuan Qin
JournalThe Journal of infectious diseases (J Infect Dis) Vol. 209 Issue 2 Pg. 236-42 (Jan 15 2014) ISSN: 1537-6613 [Electronic] United States
PMID24218506 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Neutralizing
  • Antibodies, Viral
Topics
  • Animals
  • Antibodies, Neutralizing (blood)
  • Antibodies, Viral (blood)
  • Coronavirus (physiology)
  • Coronavirus Infections (pathology, virology)
  • Disease Models, Animal
  • Histocytochemistry
  • Macaca mulatta
  • Virus Replication

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