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Mouse alpha 1-protease inhibitor is not an acute phase reactant.

Abstract
Mouse plasma contains two major protease inhibitors, alpha 1-protease inhibitor (alpha 1-PI) and contrapsin, which have high affinity for bovine trypsin. Systemic injury, such as turpentine-induced inflammation, did not change the plasma concentration of alpha 1-PI, but increased that of contrapsin by 50%. The concentration of hepatic alpha 1-PI mRNA was determined by Northern blot hybridization and was not significantly affected by the acute phase reaction. J.M. Frazer, S.A. Nathoo, J. Katz, T.L. Genetta, and T.H. Finley [1985) Arch. Biochem. Biophys. 239, 112-119) have reported a threefold increase of mRNA for the elastase specific alpha 1-PI but this increase was not demonstrated by the present study. The mRNAs for known mouse acute phase plasma proteins were, however, stimulated severalfold by the same treatment. These results indicate that in the mouse, as opposed to human, alpha 1-PI is not an acute phase reactant.
AuthorsH Baumann, J J Latimer, M D Glibetic
JournalArchives of biochemistry and biophysics (Arch Biochem Biophys) Vol. 246 Issue 1 Pg. 488-93 (Apr 1986) ISSN: 0003-9861 [Print] United States
PMID2421641 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Acute-Phase Proteins
  • Blood Proteins
  • RNA, Messenger
  • Serpins
  • Trypsin Inhibitors
  • alpha 1-Antitrypsin
  • contrapsin
  • DNA
Topics
  • Acute-Phase Proteins
  • Animals
  • Blood Proteins (biosynthesis, metabolism)
  • DNA
  • Immunoelectrophoresis, Two-Dimensional
  • Inflammation (blood)
  • Liver (metabolism)
  • Male
  • Mice
  • Mice, Inbred C57BL
  • RNA, Messenger (metabolism)
  • Serpins
  • Trypsin Inhibitors (blood)
  • alpha 1-Antitrypsin

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