Emerging roles of orphan nuclear receptors in cancer.

Abstract

A growing body of evidence suggests that a subset of orphan nuclear receptors are amplified and prognostic for some human cancers. However, the specific roles of these orphan nuclear receptors in tumor progression and their utility as drug targets are not fully understood. In this review, we summarize recent progress in elucidating the direct and indirect involvement of orphan nuclear receptors in cancer as well as their therapeutic potential in a variety of human cancers. Furthermore, we contrast the role of orphan nuclear receptors in cancer with the known roles of estrogen receptor and androgen receptor in hormone-dependent cancers.

• Authors: Sung Hee Baek, Keun Il Kim
• Journal: Annual review of physiology (Annu Rev Physiol) Vol. 76 Pg. 177-95 ( 2014) ISSN: 1545-1585 [Electronic] United States
• PMID: 24215441 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antineoplastic Agents
• Orphan Nuclear Receptors
• Receptors, Androgen
• Receptors, Estrogen

Topics

• Animals
• Antineoplastic Agents (pharmacology)
• Humans
• Neoplasms (drug therapy, genetics, physiopathology)
• Orphan Nuclear Receptors (drug effects, genetics, physiology)
• Receptors, Androgen (physiology)
• Receptors, Estrogen (physiology)