HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Langerhans cell sarcoma of the nasopharynx: a rare case.

Abstract
Langerhans cell sarcoma, a tumour with markedly malignant cytological features that originates from Langerhans cells, is a very rare disease. We report the first case of 39-year-old male with Langerhans cell sarcoma arising in the nasopharynx. We chose the 2-chlorodeoxyadenosine (2-CDA) regimen as first-line chemotherapy, and clinical improvement of Langerhans cell sarcoma was obtained. After the fourth cycle of 2-CDA therapy, however, disease progression was observed, and we administered ESHAP regimen (etoposide, carboplatin, cytarabine, methylprednisolone) as a second-line therapy. After we administered two cycles of ESHAP, however, the patient developed aggressive progression and he died. The importance of immunohistochemical findings is obvious in Langerhans cell sarcoma diagnosis. Considering that Langerhans cell sarcoma behaves in a very malignant fashion, a more aggressive treatment approach is necessary for patients with Langerhans cell sarcoma.
AuthorsM Keklik, S Sivgin, O Kontas, U Abdulrezzak, L Kaynar, M Cetin
JournalScottish medical journal (Scott Med J) Vol. 58 Issue 4 Pg. e17-20 (Nov 2013) ISSN: 0036-9330 [Print] Scotland
PMID24215052 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Cytarabine
  • Cladribine
  • Etoposide
  • Cisplatin
  • Prednisone
Topics
  • Adult
  • Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
  • Cisplatin (administration & dosage)
  • Cladribine (administration & dosage)
  • Cytarabine (administration & dosage)
  • Disease Progression
  • Etoposide (administration & dosage)
  • Fatal Outcome
  • Humans
  • Langerhans Cell Sarcoma (drug therapy, pathology)
  • Male
  • Nasopharyngeal Neoplasms (drug therapy, pathology)
  • Prednisone (administration & dosage)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: