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Astilbin protects diabetic rat heart against ischemia-reperfusion injury via blockade of HMGB1-dependent NF-κB signaling pathway.

Abstract
Astilbin, a flavonoid compound was isolated from the rhizome of Smilax china L. In this study, we investigated the anti-myocardial ischemia and reperfusion (I/R) injury effect of Astilbin on diabetic rats in vivo and elucidated the potential mechanism in vitro. The results showed that Astilbin significantly attenuated hypoxia-induced cell injury in a concentration-dependent manner. Treatment of H9c2 cells with Astilbin at 15 μM blocked nuclear factor kappaB (NF-κB) phosphorylation by blocking High-mobility group box protein 1 (HMGB1) expression. Treatment of diabetic rats with Astilbin by intravenous injection (i.v.) at a single dose of 50 mg/kg protected the rats from myocardial I/R injury as indicated by decreasing infarct volume, improving hemodynamics and reducing myocardial damage, and also lowered serum levels of pro-inflammatory factors, reduced HMGB1 and phosphorylated NF-κB expression in ischemic myocardial tissue from diabetic rats. Additionally, treatment of diabetic rats with Astilbin at dose of 50 mg/kg by i.v. for continuous 14 days attenuated cardiac remodeling in the model myocardial I/R injury. These protective effects suggested that Astilbin might be due to block of the myocardial inflammatory cascade via the HMGB1-dependent NF-κB signaling pathway.
AuthorsHuiling Diao, ZeChun Kang, Fang Han, Wanglin Jiang
JournalFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol) Vol. 63 Pg. 104-10 (Jan 2014) ISSN: 1873-6351 [Electronic] England
PMID24211745 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2013 Elsevier Ltd. All rights reserved.
Chemical References
  • Flavonols
  • HMGB1 Protein
  • Hbp1 protein, rat
  • Inflammation Mediators
  • NF-kappa B
  • astilbin
Topics
  • Animals
  • Blotting, Western
  • Diabetes Mellitus, Experimental (complications)
  • Flavonols (pharmacology)
  • HMGB1 Protein (physiology)
  • Heart (drug effects)
  • Inflammation Mediators (blood)
  • Male
  • Myocardial Reperfusion Injury (prevention & control)
  • NF-kappa B (metabolism)
  • Phosphorylation
  • Rats
  • Rats, Sprague-Dawley
  • Signal Transduction (drug effects)

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