[Treatment of high myopic choroidal neovascularisation with intravitreal bevacizumab].

Abstract

PURPOSE:

To evaluate the safety and efficacy of intravitreal bevacizumab (IVB) in the treatment of high myopic choroidal neovascularization (CNV).

MATERIALS AND METHODS:

Retrospective study of 16 eyes of 16 patients with high myopic choroidal neovascularization treated with first-line IVB (1.25mg/0.05mL) with a one-year follow-up. All patients underwent a complete baseline (M0) ophthalmologic examination, including the measurement of best corrected visual acuity (BCVA), biomicroscopic and fundus examination, fluorescein and indocyanine green angiography, and optical coherence tomography. Patients were followed monthly. Additional IVB was administered when persistent or additional retinal exudation was observed. The main study parameters were visual acuity at 1, 6 and 12 months and the progression of exudation on OCT and angiography.

RESULTS:

Mean age was 63±14 years and spherical equivalent was -15.4±7.4 diopters. Baseline BCVA was 0.75±0.5 logMAR. Mean follow-up was 15±2 months. The average number of IVB was 2.4±1.2 injections. Metamorphopsia decreased in all patients and completely disappeared in fourteen eyes. Mean BCVA was 0.5±0.3 logMAR at M1 and 0.6±0.5 logMAR at M6 and M12. No adverse events related to the intravitreal injections were observed.

CONCLUSION:

Our study showed that IVB (Avastin(®)) is effective in the treatment of high myopic CNV. Moreover, only a small number of intravitreal injections were required to treat this condition.

• Authors: B Mathieu, R Isaico, J-C Ramel, A-M Bron, C Creuzot-Garcher
• Journal: Journal francais d'ophtalmologie (J Fr Ophtalmol) Vol. 37 Issue 1 Pg. 54-7 (Jan 2014) ISSN: 1773-0597 [Electronic] France
• Vernacular Title: Traitement des néovaisseaux choroïdiens du myope fort par injection intravitréenne de bevacizumab.
• PMID: 24210931 (Publication Type: English Abstract, Journal Article)
• Copyright: Copyright © 2013 Elsevier Masson SAS. All rights reserved.

Chemical References

• Antibodies, Monoclonal, Humanized
• Bevacizumab

Topics

• Aged
• Antibodies, Monoclonal, Humanized (administration & dosage)
• Bevacizumab
• Choroidal Neovascularization (complications, drug therapy)
• Female
• Humans
• Intravitreal Injections
• Male
• Middle Aged
• Myopia, Degenerative (complications, drug therapy)
• Retrospective Studies
• Treatment Outcome
• Visual Acuity (drug effects)