Cytotoxic compounds from invasive giant salvinia (Salvinia molesta) against human tumor cells.

Abstract

Giant salvinia (Salvinia molesta) is one of the most noxious invasive species in the world. Our bioactivity-guided fractionation of ethanol extract of giant salvinia led to the isolation of 50 compounds. Of the six new compounds (1-6), salviniol (1) is a rare abietane diterpene with a new ferruginol-menthol coupled skeleton and both salviniside I (2) and salviniside II (3) are novel benzofuran glucose conjugates with unique 10-membered macrodiolide structures. Sixteen abietane diterpenes (1, 7-17, and 19-22) demonstrated in vitro activities against human tumor cells, and 7 and 8 showed selective cytotoxicity to tumor cells over normal cells.

• Authors: Shiyou Li, Ping Wang, Guangrui Deng, Wei Yuan, Zushang Su
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 23 Issue 24 Pg. 6682-7 (Dec 15 2013) ISSN: 1464-3405 [Electronic] England
• PMID: 24210499 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
• Copyright: Copyright © 2013 Elsevier Ltd. All rights reserved.

Chemical References

• Abietanes
• Antineoplastic Agents, Phytogenic
• Benzofurans
• Diterpenes
• Glucosides
• Macrolides
• Plant Extracts
• ferruginol
• salviniol
• Menthol

Topics

• Abietanes (chemistry, isolation & purification, toxicity)
• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, toxicity)
• Benzofurans (chemistry, isolation & purification, toxicity)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Diterpenes (chemistry, isolation & purification, toxicity)
• Glucosides (chemistry, isolation & purification, toxicity)
• Humans
• Introduced Species
• Macrolides (chemistry, isolation & purification, toxicity)
• Magnetic Resonance Spectroscopy
• Menthol (chemistry)
• Molecular Conformation
• Plant Extracts (toxicity)
• Tracheophyta (chemistry, metabolism)