Abstract | BACKGROUND: METHODS: Lactating multiparous Holstein cows (N = 40), with body condition scores (BCS) from 2 to 4 (eight cows for each 0.5 score increment) were enrolled. Body condition was monitored for all cows weekly for 7 weeks post calving; cows with uterine inflammatory conditions were also re-evaluated 2 weeks later. Blood samples were collected from 1 week prior to calving to 7 weeks after calving for determination of serum concentrations of adipokines, insulin and insulin like growth factor (IGF)-1. RESULTS: Cows with metritis or clinical endometritis had higher serum concentrations of adiponectin, leptin, TNF-alpha, IL-1beta and IL-6 compared to normal cows (P < 0.05). Furthermore, serum leptin, TNF-alpha, IL-1beta and IL-6 were higher in cows with subclinical endometritis compared to normal cows (P < 0.05), and insulin and IGF-1 concentrations were lower in cows with metritis or clinical endometritis. Cows with low BCS (2 and 2.5) had significantly higher adiponectin, TNF-alpha, IL-1beta and IL-6 than those with high BCS (3 to 4). Cows with persistent uterine inflammatory conditions had higher adiponectin, leptin TNF-alpha, IL-1beta and IL-6 and insulin compared to normal and spontaneously recovered cows, except for IGF-1 (P < 0.05). CONCLUSIONS: Serum concentrations of adipokines, insulin, and IGF-1 had significant associations with BCS categories (low vs. high) and postpartum uterine inflammatory conditions. Perhaps loss of body condition mediated increases in anti- and pro-inflammatory cytokines, whereas increased pro- and anti-inflammatory cytokines concentrations mediated body condition loss and thereby prolonged persistence of uterine inflammation in dairy cows.
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Authors | Ramanathan K Kasimanickam, Vanmathy R Kasimanickam, Jesse R Olsen, Erin J Jeffress, Dale A Moore, John P Kastelic |
Journal | Reproductive biology and endocrinology : RB&E
(Reprod Biol Endocrinol)
Vol. 11
Pg. 103
(Nov 09 2013)
ISSN: 1477-7827 [Electronic] England |
PMID | 24209779
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adipokines
- Cytokines
- Insulin
- Insulin-Like Growth Factor I
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Topics |
- Adipokines
(blood)
- Animals
- Body Constitution
- Cattle
- Cattle Diseases
(blood)
- Cytokines
(blood)
- Female
- Insulin
(blood)
- Insulin-Like Growth Factor I
(metabolism)
- Postpartum Period
(blood)
- Uterine Diseases
(blood, veterinary)
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