HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Rituximab for refractory autoimmune hepatitis: a case report.

Abstract
Auto-immune hepatitis (AIH) is a chronic progressive hepatitis of unknown aetiology whose clinical presentation ranges from asymptomatic to fulminant hepatic failure. Corticosteroids and azathioprine, which are considered standard therapy for AIH, may, however, be associated with treatment failures and toxicities. Among the alternative medications under investigation, rituximab, used to treat successfully various auto-immune disorders, has fewer side effects. We report herein the case of a 68-year-old woman who developed AIH with worsening clinical, laboratory and histological features despite high-dose prednisone. On rituximab, the patient showed rapid and dramatic clinical improvement, suggesting a therapeutic role for this medication in severe AIH. Indeed, prospective controlled studies are needed to assess and validate this role.
AuthorsSaid A Al-Busafi, René P Michel, Marc Deschenes
JournalArab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology (Arab J Gastroenterol) Vol. 14 Issue 3 Pg. 135-8 (Sep 2013) ISSN: 2090-2387 [Electronic] Egypt
PMID24206745 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright © 2013 Arab Journal of Gastroenterology. Published by Elsevier Ltd. All rights reserved.
Chemical References
  • Anti-Inflammatory Agents
  • Antibodies, Monoclonal, Murine-Derived
  • Immunologic Factors
  • Rituximab
  • Prednisone
Topics
  • Aged
  • Anti-Inflammatory Agents (therapeutic use)
  • Antibodies, Monoclonal, Murine-Derived (therapeutic use)
  • Female
  • Hepatitis, Autoimmune (drug therapy, pathology)
  • Humans
  • Immunologic Factors (therapeutic use)
  • Prednisone (therapeutic use)
  • Rituximab
  • Treatment Failure

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: