Thrombomodulin is a Strong Predictor of Multiorgan Dysfunction Syndrome in Patients With Sepsis.

Abstract

BACKGROUND:

Biomarkers of endothelial dysfunction are not recommended for routine laboratory investigation of the outcome prognosis and prediction of the course of sepsis.

METHODS:

A total of 60 patients who fulfilled the criteria for diagnosis of sepsis were included in our study. Development of multiorgan dysfunction syndrome (MODS) in the first 48 hours was assessed. Differences between groups of patients with sepsis were assessed by Mann-Whitney U test and by Kruskal-Wallis test. Logistic regression analysis was performed to test the joint effect of different predictors.

RESULTS:

Level of thrombomodulin was significantly higher in group of patients with MODS than without MODS (P = .015). Levels of antithrombin (P = .026) and protein C (P = .035) were significantly lower in patients with MODS. Level of thrombomodulin was the strongest predictor in MODS development in first 48 hours (P = .028).

CONCLUSION:

The level of thrombomodulin not only was able to distinguish the severity of sepsis but also was a significant predictor of MODS development.

• Authors: Dunja M Mihajlovic, Dajana F Lendak, Biljana G Draskovic, Aleksandra S Novakov Mikic, Gorana P Mitic, Tatjana N Cebovic, Snezana V Brkic
• Journal: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis (Clin Appl Thromb Hemost) Vol. 21 Issue 5 Pg. 469-74 (Jul 2015) ISSN: 1938-2723 [Electronic] United States
• PMID: 24203354 (Publication Type: Journal Article)
• Copyright: © The Author(s) 2013.

Chemical References

• Thrombomodulin

Topics

• Female
• Hemostasis
• Humans
• Male
• Middle Aged
• Multiple Organ Failure (blood)
• Prospective Studies
• Sepsis (blood)
• Thrombomodulin (analysis, blood)
• Thrombophilia