Abstract | BACKGROUND:
Biomarkers of endothelial dysfunction are not recommended for routine laboratory investigation of the outcome prognosis and prediction of the course of sepsis. METHODS: A total of 60 patients who fulfilled the criteria for diagnosis of sepsis were included in our study. Development of multiorgan dysfunction syndrome ( MODS) in the first 48 hours was assessed. Differences between groups of patients with sepsis were assessed by Mann-Whitney U test and by Kruskal-Wallis test. Logistic regression analysis was performed to test the joint effect of different predictors. RESULTS: CONCLUSION: The level of thrombomodulin not only was able to distinguish the severity of sepsis but also was a significant predictor of MODS development.
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Authors | Dunja M Mihajlovic, Dajana F Lendak, Biljana G Draskovic, Aleksandra S Novakov Mikic, Gorana P Mitic, Tatjana N Cebovic, Snezana V Brkic |
Journal | Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
(Clin Appl Thromb Hemost)
Vol. 21
Issue 5
Pg. 469-74
(Jul 2015)
ISSN: 1938-2723 [Electronic] United States |
PMID | 24203354
(Publication Type: Journal Article)
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Copyright | © The Author(s) 2013. |
Chemical References |
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Topics |
- Female
- Hemostasis
- Humans
- Male
- Middle Aged
- Multiple Organ Failure
(blood)
- Prospective Studies
- Sepsis
(blood)
- Thrombomodulin
(analysis, blood)
- Thrombophilia
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