Is there any association between thrombosis and tissue factor pathway inhibitor levels in patients with vitamin D deficiency?

Abstract

OBJECTIVE:

The aim of this study was to evaluate the relationship between vitamin D levels and hemostatic factors like tissue factor pathway inhibitor (TFPI).

METHODS:

Patients who had 25-hydroxyvitamin D3 (25(OH)D3) levels measured were included. Coagulation and hemostatic parameters were evaluated. Patients were divided into 3 groups based on 25(OH)D3 levels as group 1 (25(OH)D3 < 10 ng/mL, n = 25), group 2 (25(OH)D3 = 10-19.9 ng/mL, n = 22), and group 3 (25(OH)D3 ≥ 20 ng/mL, n = 28).

RESULTS:

A total of 75 patients with a mean age of 39 (range 18-57) years were included in the study. Prothrombin time was longer in group 3 than in group 2 (P = .043). The TFPI levels were higher in group 3 than in the other groups (P < .001). There was a strong positive correlation between 25(OH)D3 and TFPI levels (r = .47, P < .001).

CONCLUSION:

Further studies are needed for evaluation of the role of TFPI in hemostasis and thrombotic process in patients with vitamin D deficiency.

• Authors: Oya Topaloglu, Muyesser Sayki Arslan, Melia Karakose, Bekir Ucan, Zeynep Ginis, Evrim Cakir, Esra Tutal Akkaymak, Mustafa Sahin, Mustafa Ozbek, Erman Cakal, Tuncay Delibasi
• Journal: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis (Clin Appl Thromb Hemost) Vol. 21 Issue 5 Pg. 428-33 (Jul 2015) ISSN: 1938-2723 [Electronic] United States
• PMID: 24203351 (Publication Type: Journal Article)
• Copyright: © The Author(s) 2013.

Chemical References

• Lipoproteins
• lipoprotein-associated coagulation inhibitor

Topics

• Adult
• Cross-Sectional Studies
• Female
• Humans
• Lipoproteins (blood, genetics)
• Male
• Thrombosis (blood, etiology)
• Vitamin D Deficiency (blood)