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[Complete remission obtained in advanced testicular cancer treated by etoposide (NK-171)]

AbstractA 38-year-old man was admitted to Nara Medical University Hospital on Feb.7,1983, because of swelling of the scrotal contents on the right side and elevated serum AFP, beta-HCG and LDH suggestive of testicular tumor. Right orchiectomy was carried out and a pathological diagnosis of embryonal cell carcinoma of the right testis (pT3N0M1) was made. The patient, upon evidence of multiple pulmonary metastases, was treated with a combination chemotherapy of cis-Diamminedichloroplatinum, vincristine and peplomycin. After three courses of combination chemotherapy, pulmonary metastases were decreased, but their foci persisted. The patient was then treated with Etoposide 62 mg/m2 daily for 5 days every three weeks, and after this course, complete remission of pulmonary metastases was obtained. The patient recieved 3 courses of Etoposide and retroperitoneal lymph node dissection, and has since shown no evidence of disease for 2 years and 4 months after surgery.
AuthorsK Babaya, K Tsumatani, O Natsume, T Yoshie, K Kubota, S Ozono, Y Hirao, E Okajima
JournalGan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 13 Issue 3 Pt 1 Pg. 604-7 (Mar 1986) ISSN: 0385-0684 JAPAN
PMID2420282 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Bleomycin
  • Cisplatin
  • Etoposide
  • Podophyllotoxin
  • Vincristine
  • Peplomycin
Topics
  • Adult
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Bleomycin (administration & dosage)
  • Cisplatin (administration & dosage)
  • Combined Modality Therapy
  • Drug Administration Schedule
  • Etoposide (therapeutic use)
  • Humans
  • Lung Neoplasms (secondary)
  • Lymph Node Excision
  • Male
  • Peplomycin
  • Podophyllotoxin (analogs & derivatives)
  • Teratoma (drug therapy, pathology, surgery)
  • Testicular Neoplasms (drug therapy, pathology, surgery)
  • Vincristine (administration & dosage)