Contact allergy to 3-methylol phenol, 2,4-dimethylol phenol and 2,6-dimethylol phenol.

Abstract

Thirteen patients with contact allergy to phenol-formaldehyde resins (P-F-R) were patch tested with 3-methylol phenol, 2,4-dimethylol phenol and 2,6-dimethylol phenol. Nine patients reacted to at least 1 compound, all giving positive test responses to 2,4-dimethylol phenol. Seven patients reacted simultaneously to 2,6-dimethylol phenol while only 1 patient reacted to 3-methylol phenol. Negative test responses were noted in 20 controls. Chemical investigation by high pressure liquid chromatography indicated that the compounds tested were pure and separable. The 3 reported sensitizers may, theoretically, be generated during the manufacture of P-F-R. 2,4-Dimethylol phenol and 2,6-dimethylol phenol have been demonstrated and there has been chromatographic evidence of 3-methylol phenol in the P-F-R used in the routine test series at the department.

• Authors: M Bruze, E Zimerson
• Journal: Acta dermato-venereologica (Acta Derm Venereol) Vol. 65 Issue 6 Pg. 548-51 ( 1985) ISSN: 0001-5555 [Print] Sweden
• PMID: 2420124 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Benzyl Alcohols
• Benzyl Compounds
• Phenols
• Polymers
• Formaldehyde
• 2,6-dimethylol phenol
• 3-hydroxybenzyl alcohol
• phenol-formaldehyde resin
• 2,4-dimethylol phenol

Topics

• Benzyl Alcohols (immunology)
• Benzyl Compounds (immunology)
• Dermatitis, Contact (immunology)
• Dermatitis, Occupational (immunology)
• Formaldehyde (immunology)
• Humans
• Patch Tests
• Phenols (immunology)
• Polymers (immunology)