Plasma coenzyme Q10 levels in type 2 diabetic patients with retinopathy.

Abstract

AIM:

To determine the relationship between proliferative diabetic retinopathy (PDRP) and plasma coenzyme Q10(CoQ10) concentration.

METHODS:

Patients with type 2 diabetes and PDRP were determined to be the case group (n=50). The control group was consist of healthy individuals (n=50). Plasma CoQ10 and malondialdehyde (MDA) levels were measured in both groups.

RESULTS:

Ubiquinone-10 (Coenzyme Q10) levels in PDRP and control subjects are 3.81±1.19µmol/L and 1.91±0.62µmol/L, respectively. Plasma MDA levels in PDRP and control subjects were 8.16±2µmol/L and 3.44±2.08µmol/L, respectively. Ratio of Ubiquinol-10/ubiquinone-10 in PDRP and control subjects were 0.26±0.16 and 1.41±0.68, respectively.

CONCLUSION:

The ratio of ubiquinol-10/ubiquinone-10 is found lower in patients with PDRP. High levels of plasma ubiquinol-10/ubiquinone-10 ratio indicate the protective effect on diabetic retinopathy.

• Authors: Orhan Ates, Habip Bilen, Sadullah Keles, H Hakan Alp, Mevlüt Sait Keleş, Kenan Yıldırım, Osman Ondaş, L Can Pınar, Mustafa Civelekler, Orhan Baykal
• Journal: International journal of ophthalmology (Int J Ophthalmol) Vol. 6 Issue 5 Pg. 675-9 ( 2013) ISSN: 2222-3959 [Print] China
• PMID: 24195048 (Publication Type: Journal Article)