Abstract |
The effects of hypoxia on metabolism of 5-hydroxytryptamine (5-HT or serotonin) and 3,4-dihydroxyphenylethylamine (DA or dopamine) were compared with those on open-field activity in male CD-1 mice. Chemical hypoxia was induced with NaNO2. Hypoxia did not alter striatal concentrations of DA, 5HT, Trp, Tyr, 5-hydroxyindoleacetic acid, or homovanillic acid. However, NaNO2 (75 mg/kg) reduced the rates of conversion of [3H]Tyr to [3H]DA (-41%) and [3H]Trp to [3H]5-HT (-39%). Hypoxia also reduced dihydroxyphenylacetic acid ( DOPAC) levels (-27%) and DOPAC/DA ratios (-20%). Open-field behavior, as measured in an automated activity monitor, decreased in a dose-dependent fashion with 75-150 mg/kg of NaNO2 (-35 to -90%). Comparison with previous studies suggests that the syntheses of dopamine, serotonin, and the amino acids are equally vulnerable to hypoxic insults but may be less sensitive than the synthesis of acetylcholine.
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Authors | G B Freeman, P Nielsen, G E Gibson |
Journal | Journal of neurochemistry
(J Neurochem)
Vol. 46
Issue 3
Pg. 733-8
(Mar 1986)
ISSN: 0022-3042 [Print] England |
PMID | 2419497
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Nitrates
- 3,4-Dihydroxyphenylacetic Acid
- Serotonin
- Tyrosine
- Hydroxyindoleacetic Acid
- Tryptophan
- sodium nitrate
- Dopamine
- Homovanillic Acid
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Topics |
- 3,4-Dihydroxyphenylacetic Acid
(metabolism)
- Animals
- Corpus Striatum
(metabolism)
- Dopamine
(metabolism)
- Homovanillic Acid
(metabolism)
- Hydroxyindoleacetic Acid
(metabolism)
- Hypoxia
(chemically induced, physiopathology)
- Male
- Mice
- Motor Activity
(physiology)
- Nitrates
- Serotonin
(metabolism)
- Tryptophan
(metabolism)
- Tyrosine
(metabolism)
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