Abstract | BACKGROUND: METHODS: RESULTS: In phase 1, after 1 year of treatment a similarly substantial BP decrease was seen in the candesartan (-24.5/16.1 mm Hg) and nifedipine (-26.8/18.0 mm Hg) groups. In phase 2 there was a substantial reoccurrence of hypertension; at the study end, only 1 patient was able to continue without antihypertensive medication. However, a Kaplan-Meier analysis revealed a significant delay of reoccurrence of hyper tension (P = 0.0001) in the candesartan group. CONCLUSIONS: One year of treatment with candesartan or nifedipine CR was not associated with marked regression of hypertension in humans at the standard doses used in this trial. However, withdrawal of candesartan was associated with a slightly longer delay before restarting medications. Further studies with larger doses of candesartan given over a longer time are required to determine whether such a regimen may induce sustainable and clinically relevant reversal of hypertension and alteration in its natural history.
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Authors | Hiroyuki Sasamura, Hideaki Nakaya, Stevo Julius, Naoki Tomotsugu, Yuji Sato, Fumiaki Takahashi, Masahiro Takeuchi, Marohito Murakami, Munekazu Ryuzaki, Hiroshi Itoh, STAR CAST investigators |
Journal | American journal of hypertension
(Am J Hypertens)
Vol. 26
Issue 12
Pg. 1381-8
(Dec 2013)
ISSN: 1941-7225 [Electronic] United States |
PMID | 24190927
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antihypertensive Agents
- Benzimidazoles
- Biphenyl Compounds
- Tetrazoles
- Nifedipine
- candesartan
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Topics |
- Adult
- Antihypertensive Agents
(administration & dosage, therapeutic use)
- Benzimidazoles
(administration & dosage, therapeutic use)
- Biphenyl Compounds
- Blood Pressure
(drug effects)
- Blood Pressure Determination
- Double-Blind Method
- Drug Administration Schedule
- Feasibility Studies
- Female
- Follow-Up Studies
- Humans
- Hypertension
(diet therapy, drug therapy, physiopathology)
- Japan
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Nifedipine
(administration & dosage, therapeutic use)
- Prospective Studies
- Tetrazoles
(administration & dosage, therapeutic use)
- Treatment Outcome
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