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[Comparison of CA 50 and CA 19-9 tumor markers in benign and malignant diseases of the upper gastrointestinal tract].

Abstract
Tumour-associated antigens CA 50 and CA 19-9 were determined in serum of 208 patients. Specificity of both neo-antigens as tumour markers was equally good, at 100% and 95%, in patients without malignancy or gastrointestinal disease, respectively, using an upper limit of normal of 17 U/ml for CA 50 and 37 U/ml for CA 19-9. Benign diseases of the upper gastrointestinal tract, such as pancreatitis, cholestasis or cirrhosis of the liver, reduce the specificity of CA 50 more than of CA 19-9. For example, specificity of CA 50 is only 33% for choledocholithiasis, but 74% with CA 19-9. The sensitivity of both closely related sialogangliosides in malignancies of the upper GI tract is similar, with the usual normal limits: in pancreas carcinoma 77% for CA 50, 81% for CA 19-9; in biliary tract carcinoma 80% for CA 50, 90% for CA 19-9; in gastric carcinoma 40% for CA 50, 50% for CA 19-9. But if one equalizes the upper limits of normal for both markers to a common 95% specificity, the tumour-indicating sensitivity of CA 19-9 clearly surpasses that of CA 50. Malignant tumours not recognized by increased levels of CA 19-9 also escape serological diagnosis with CA 50.
AuthorsG Heptner, S Domschke, M U Schneider, W Siegfried, W Domschke
JournalDeutsche medizinische Wochenschrift (1946) (Dtsch Med Wochenschr) Vol. 111 Issue 10 Pg. 374-8 (Mar 07 1986) ISSN: 0012-0472 [Print] Germany
Vernacular TitleVergleich der Tumormarker CA 50 und CA 19-9 bei benignen und malignen Erkrankungen des oberen Gastrointestinaltraktes.
PMID2419074 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • Antigens, Neoplasm
  • Antigens, Tumor-Associated, Carbohydrate
  • Epitopes
  • Gangliosides
  • sialogangliosides
Topics
  • Adult
  • Aged
  • Antigens, Neoplasm (analysis)
  • Antigens, Tumor-Associated, Carbohydrate
  • Diagnosis, Differential
  • Epitopes (analysis)
  • Female
  • Gallstones (diagnosis)
  • Gangliosides (analysis, immunology)
  • Gastrointestinal Neoplasms (diagnosis)
  • Humans
  • Liver Cirrhosis (diagnosis)
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Pancreatitis (diagnosis)

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