Abstract |
Tumour-associated antigens CA 50 and CA 19-9 were determined in serum of 208 patients. Specificity of both neo- antigens as tumour markers was equally good, at 100% and 95%, in patients without malignancy or gastrointestinal disease, respectively, using an upper limit of normal of 17 U/ml for CA 50 and 37 U/ml for CA 19-9. Benign diseases of the upper gastrointestinal tract, such as pancreatitis, cholestasis or cirrhosis of the liver, reduce the specificity of CA 50 more than of CA 19-9. For example, specificity of CA 50 is only 33% for choledocholithiasis, but 74% with CA 19-9. The sensitivity of both closely related sialogangliosides in malignancies of the upper GI tract is similar, with the usual normal limits: in pancreas carcinoma 77% for CA 50, 81% for CA 19-9; in biliary tract carcinoma 80% for CA 50, 90% for CA 19-9; in gastric carcinoma 40% for CA 50, 50% for CA 19-9. But if one equalizes the upper limits of normal for both markers to a common 95% specificity, the tumour-indicating sensitivity of CA 19-9 clearly surpasses that of CA 50. Malignant tumours not recognized by increased levels of CA 19-9 also escape serological diagnosis with CA 50.
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Authors | G Heptner, S Domschke, M U Schneider, W Siegfried, W Domschke |
Journal | Deutsche medizinische Wochenschrift (1946)
(Dtsch Med Wochenschr)
Vol. 111
Issue 10
Pg. 374-8
(Mar 07 1986)
ISSN: 0012-0472 [Print] Germany |
Vernacular Title | Vergleich der Tumormarker CA 50 und CA 19-9 bei benignen und malignen Erkrankungen des oberen Gastrointestinaltraktes. |
PMID | 2419074
(Publication Type: Comparative Study, English Abstract, Journal Article)
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Chemical References |
- Antigens, Neoplasm
- Antigens, Tumor-Associated, Carbohydrate
- Epitopes
- Gangliosides
- sialogangliosides
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Topics |
- Adult
- Aged
- Antigens, Neoplasm
(analysis)
- Antigens, Tumor-Associated, Carbohydrate
- Diagnosis, Differential
- Epitopes
(analysis)
- Female
- Gallstones
(diagnosis)
- Gangliosides
(analysis, immunology)
- Gastrointestinal Neoplasms
(diagnosis)
- Humans
- Liver Cirrhosis
(diagnosis)
- Lymphatic Metastasis
- Male
- Middle Aged
- Neoplasm Staging
- Pancreatitis
(diagnosis)
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