Partial restoration of pancreatic function by exogenous secretin in rats with ceruletide-induced acute pancreatitis.

Pharmacological doses of ceruletide administered intravenously to unconscious rats uniformly induces acute pancreatitis (AP) as well as a striking reduction in pure pancreatic juice (PPJ) and protein output. High-dose intravenous secretin administered to rats with ceruletide-induced AP effects a reestablishment of PPJ flow and a significant increase in PPJ protein output. Light microscopy of the pancreas in ceruletide-induced AP rats revealed marked acinar cell vacuolization and intense interstitial edema. By contrast, pancreatic histology in AP rats treated with high-dose secretin revealed a distinct lessening of acinar cell vacuolization and interstitial edema. We have established that high-dose intravenous secretin given to rats with ceruletide-induced AP is (1) not harmful, (2) reestablishes PPJ flow and evokes a partial restoration of protein output, and (3) appears to reduce pancreatic histopathology when compared to non-secretin-treated rats with AP.
AuthorsI G Renner, J R Wisner Jr, B C Lavigne
JournalDigestive diseases and sciences (Dig Dis Sci) Vol. 31 Issue 3 Pg. 305-13 (Mar 1986) ISSN: 0163-2116 [Print] UNITED STATES
PMID2419062 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Proteins
  • Secretin
  • Ceruletide
  • Amylases
  • Acute Disease
  • Amylases (blood)
  • Animals
  • Ceruletide
  • Disease Models, Animal
  • Infusions, Parenteral
  • Male
  • Pancreas (drug effects, pathology, physiopathology)
  • Pancreatic Juice (secretion)
  • Pancreatitis (chemically induced, physiopathology)
  • Proteins (secretion)
  • Rats
  • Rats, Inbred Strains
  • Secretin (administration & dosage)
  • Time Factors

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