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Effect of huanglianjiedu tang on fever in rats induced by 2, 4-dinitrophenol.

AbstractOBJECTIVE:
To study metabolic characteristics of fever in rats induced by 2, 4-dinitrophenol (DNP) and the effect of Huanglianjiedu Tang (HLJDT) on the fever.
METHODS:
The urine samples were analyzed by ultra-performance liquid chromatography/electrospray ionization quadruple time-of-flight mass spectrometry (UPLC/ESI-Q-TOF-MS) at the positive ion mode scanning, and experimental data were analyzed by the principal component analysis.
RESULTS:
Eight potential biomarkers indicating the occurrence and evolvement of fever were determined according to ions in urine samples. Five of them were found increased, while the other three decreased. After HLJDD intervention, the increased five were reduced significantly in high dose group, compared with model group, while the decreased three had no obvious change. Five of the eight biomakers were identified with formyl-5-hydroxykynurenamine, gentisic acid, aminoadipic acid, phenylacetic acid, L-phenylalanyl-L-hydroxyproline on the basis of MS/MS. These biomarkers are associated with the metabolism of 5-hydroxytryptamine, tyrosine, lysine, phenylalanine and collagen protein, respectively.
CONCLUSION:
HLJDT had significant effect on DNP-induced fever in rats. The effect was performed possibly by acting on 5-hydroxytryptamine in hypothalamus and some amino acid metabolism. These results suggested that HLJDT relieved fever by acting on multi-targets.
AuthorsShumin Liu, Na Wang, Pingping Chen, Xuzhao Li, Changfeng Liu
JournalJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan (J Tradit Chin Med) Vol. 33 Issue 4 Pg. 492-9 (Aug 2013) ISSN: 0255-2922 [Print] China
PMID24187871 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Biomarkers
  • Dinitrophenols
  • Drugs, Chinese Herbal
Topics
  • Administration, Oral
  • Animals
  • Biomarkers (urine)
  • Chromatography, High Pressure Liquid
  • Dinitrophenols (adverse effects)
  • Drugs, Chinese Herbal (administration & dosage)
  • Fever (drug therapy, etiology, urine)
  • Humans
  • Male
  • Metabolomics
  • Rats
  • Rats, Wistar
  • Tandem Mass Spectrometry

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