Multifunctional squalene-based prodrug nanoparticles for targeted cancer therapy.

Abstract

Fluorescent and biotinylated squalene-gemcitabine prodrug nanoparticles exhibiting high drug payloads have been prepared and successfully used to target different cancer cell lines, resulting in increased cell uptake and improved anticancer efficiency, which represents the first targeted system derived from the squalenoylation approach.

• Authors: Duc Trung Bui, Julien Nicolas, Andrei Maksimenko, Didier Desmaële, Patrick Couvreur
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 50 Issue 40 Pg. 5336-8 (May 25 2014) ISSN: 1364-548X [Electronic] England
• PMID: 24185552 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antimetabolites, Antineoplastic
• Prodrugs
• Deoxycytidine
• Squalene
• Gemcitabine

Topics

• Antimetabolites, Antineoplastic (therapeutic use)
• Deoxycytidine (analogs & derivatives, therapeutic use)
• Drug Delivery Systems
• Humans
• Nanomedicine
• Nanoparticles (chemistry)
• Neoplasms (diagnosis, drug therapy, metabolism)
• Prodrugs (therapeutic use)
• Squalene (chemistry)
• Tumor Cells, Cultured
• Gemcitabine