Genomic evolution from primary breast carcinoma to distant metastasis: Few copy number changes of breast cancer related genes.

Abstract

Cancer initiation and progression is characterized by (epi)genetic aberrations. However, little is known about the changes that occur during breast cancer metastasis. In the present study, multiplex ligation-dependent probe amplification was used to compare copy numbers of 21 established oncogenes and tumor suppressor genes between 55 primary breast cancer samples and corresponding distant metastases. Distant breast cancer metastases generally showed similar gene copy number aberrations compared to their corresponding primary tumors. The few genes that showed differences between primary tumor and metastasis (PRDM14, MED1, CCNE1, TRAF4, MTDH, CDH1) have been implicated in the development of therapy resistance.

• Authors: Cathy B Moelans, Petra van der Groep, Laurien D C Hoefnagel, Marc J van de Vijver, Pieter Wesseling, Jelle Wesseling, Elsken van der Wall, Paul J van Diest
• Journal: Cancer letters (Cancer Lett) Vol. 344 Issue 1 Pg. 138-146 (Mar 01 2014) ISSN: 1872-7980 [Electronic] Ireland
• PMID: 24184827 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Topics

• Adult
• Aged
• Aged, 80 and over
• Breast Neoplasms (genetics, pathology)
• Female
• Gene Dosage
• Genes, Tumor Suppressor
• Genomics
• Humans
• Middle Aged
• Multiplex Polymerase Chain Reaction
• Neoplasm Invasiveness (genetics)
• Neoplasm Metastasis (genetics)
• Oncogenes (genetics)