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Clinical significance of autoantibodies to the pericentromeric heterochromatin protein 1a protein.

AbstractOBJECTIVE:
The objective of the study is to determine the frequency and the clinical significance of autoantibodies to the pericentromeric heterochromatin protein 1 (HP1). So far this antinuclear antibody specificity has been mainly reported in patients with the CREST syndrome.
METHODS:
We screened the sera of 199 individuals, including patients suffering from various autoimmune disorders (Group I, n=145) and non autoimmune diseases (Group II, n=44 patients) as well as healthy individuals (Group III, n=30). The sera were systematically tested by Western blot and ELISA using a GST-HP1α fusion protein as an antigen.
RESULTS:
Anti-HP1 antibodies were detected in 32% of patients in Group I, 11.3% in Group II and 3.3% of individuals in Group III. They could be detected in sera containing or not antinuclear antibodies detectable by indirect immunofluorescence. Anti-HP1 antibodies were mostly associated with the CREST and Sjogren's syndromes (70% and 44.4%, respectively). They could also be detected in 22.2% of patients suffering from various other autoimmune diseases. However, their negative predictive value was 94% in the CREST syndrome.
CONCLUSION:
Anti-HP1 autoantibodies are associated with a large spectrum of disorders. However, they have a diagnostic value in the CREST syndrome.
AuthorsPaul Coppo, Isabelle Henry-Dessailly, Jacques Rochette, Catherine Lok, Brigitte Buendia, Kaiss Lassoued
JournalEuropean journal of internal medicine (Eur J Intern Med) Vol. 24 Issue 8 Pg. 868-71 (Dec 2013) ISSN: 1879-0828 [Electronic] Netherlands
PMID24184038 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright© 2013.
Chemical References
  • Antibodies, Antinuclear
  • Autoantibodies
  • CBX5 protein, human
  • Chromosomal Proteins, Non-Histone
  • anticentromere antibody
  • Chromobox Protein Homolog 5
Topics
  • Adolescent
  • Adult
  • Aged
  • Antibodies, Antinuclear (immunology)
  • Antiphospholipid Syndrome (diagnosis, immunology)
  • Arthritis, Rheumatoid (diagnosis, immunology)
  • Autoantibodies (immunology)
  • Autoimmune Diseases (diagnosis, immunology)
  • CREST Syndrome (diagnosis, immunology)
  • Case-Control Studies
  • Chromobox Protein Homolog 5
  • Chromosomal Proteins, Non-Histone (immunology)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Scleroderma, Systemic (diagnosis, immunology)
  • Sjogren's Syndrome (diagnosis, immunology)
  • Young Adult

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