Abstract | OBJECTIVE: METHODS: We screened the sera of 199 individuals, including patients suffering from various autoimmune disorders (Group I, n=145) and non autoimmune diseases (Group II, n=44 patients) as well as healthy individuals (Group III, n=30). The sera were systematically tested by Western blot and ELISA using a GST-HP1α fusion protein as an antigen. RESULTS: Anti-HP1 antibodies were detected in 32% of patients in Group I, 11.3% in Group II and 3.3% of individuals in Group III. They could be detected in sera containing or not antinuclear antibodies detectable by indirect immunofluorescence. Anti-HP1 antibodies were mostly associated with the CREST and Sjogren's syndromes (70% and 44.4%, respectively). They could also be detected in 22.2% of patients suffering from various other autoimmune diseases. However, their negative predictive value was 94% in the CREST syndrome. CONCLUSION:
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Authors | Paul Coppo, Isabelle Henry-Dessailly, Jacques Rochette, Catherine Lok, Brigitte Buendia, Kaiss Lassoued |
Journal | European journal of internal medicine
(Eur J Intern Med)
Vol. 24
Issue 8
Pg. 868-71
(Dec 2013)
ISSN: 1879-0828 [Electronic] Netherlands |
PMID | 24184038
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2013. |
Chemical References |
- Antibodies, Antinuclear
- Autoantibodies
- CBX5 protein, human
- Chromosomal Proteins, Non-Histone
- anticentromere antibody
- Chromobox Protein Homolog 5
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Topics |
- Adolescent
- Adult
- Aged
- Antibodies, Antinuclear
(immunology)
- Antiphospholipid Syndrome
(diagnosis, immunology)
- Arthritis, Rheumatoid
(diagnosis, immunology)
- Autoantibodies
(immunology)
- Autoimmune Diseases
(diagnosis, immunology)
- CREST Syndrome
(diagnosis, immunology)
- Case-Control Studies
- Chromobox Protein Homolog 5
- Chromosomal Proteins, Non-Histone
(immunology)
- Female
- Humans
- Male
- Middle Aged
- Predictive Value of Tests
- Scleroderma, Systemic
(diagnosis, immunology)
- Sjogren's Syndrome
(diagnosis, immunology)
- Young Adult
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