Autoinflammatory bone diseases.

Abstract

Autoinflammatory bone disease is a new branch of autoinflammatory diseases caused by seemingly unprovoked activation of the innate immune system leading to an osseous inflammatory process. The inflammatory bone lesions in these disorders are characterized by chronic inflammation that is typically culture negative with no demonstrable organism on histopathology. The most common autoinflammatory bone diseases in childhood include chronic nonbacterial osteomyelitis (CNO), synovitis, acne, pustulosis, hyperostosis, osteitis syndrome, Majeed syndrome, deficiency of interleukin-1 receptor antagonist, and cherubism. In this article, the authors focus on CNO and summarize the distinct genetic autoinflammatory bone syndromes.

• Authors: Sara M Stern, Polly J Ferguson
• Journal: Rheumatic diseases clinics of North America (Rheum Dis Clin North Am) Vol. 39 Issue 4 Pg. 735-49 (Nov 2013) ISSN: 1558-3163 [Electronic] United States
• PMID: 24182852 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
• Copyright: Copyright © 2013 Elsevier Inc. All rights reserved.

Chemical References

• Interleukin 1 Receptor Antagonist Protein

Topics

• Acne Vulgaris (diagnosis, immunology, therapy)
• Acquired Hyperostosis Syndrome (diagnosis, immunology, therapy)
• Anemia, Dyserythropoietic, Congenital (diagnosis, immunology, therapy)
• Bone Diseases (diagnosis, immunology, therapy)
• Cherubism (diagnosis, immunology, therapy)
• Chronic Disease
• Hereditary Autoinflammatory Diseases (diagnosis, immunology, therapy)
• Humans
• Hyperostosis (diagnosis, immunology, therapy)
• Immunologic Deficiency Syndromes
• Inflammation
• Interleukin 1 Receptor Antagonist Protein (immunology)
• Osteitis (diagnosis, immunology, therapy)
• Osteomyelitis (diagnosis, immunology, therapy)
• Syndrome
• Synovitis (diagnosis, immunology, therapy)