Abstract | OBJECTIVE: DESIGN: Retrospective investigation. SETTING: Patients from a single tertiary medical center. PARTICIPANTS: A total of 724 patients undergoing CABG surgery met the inclusion criteria and were categorized into 2 groups: 345 in the dexmedetomidine group (DEX) and 379 in the nondexmedetomidine group (Non-DEX). INTERVENTIONS: MEASUREMENTS AND MAIN RESULTS: Major outcome measures of this study were in-hospital, 30-day and 1-year all-cause mortality, delirium and major adverse cardiocerebral events. Perioperative dexmedetomidine infusion was associated with significant reductions in in-hospital, 30-day, and 1-year mortalities, compared with the patients who did not received dexmedetomidine. In-hospital, 30-day, and 1-year mortalities were 1.5% and 4.0% (adjusted odds ratio [OR], 0.332; 95% CI, 0.155 to 0.708; p = 0.0044), 2.0% and 4.5% (adjusted OR, 0.487; 95% CI, 0.253 to 0.985; p = 0.0305), and 3.2% and 6.9% (adjusted OR 0.421; 95% CI, 0.247 to 0.718, p = 0.0015), respectively. Perioperative dexmedetomidine infusion was associated with a reduced risk of delirium from 7.9% to 4.6% (adjusted OR, 0.431; 95% CI, 0.265-0.701; p = 0.0007). CONCLUSION:
Dexmedetomidine infusion during CABG surgery was more likely to achieve improved in-hospital, 30-day, and 1-year survival rates, and a significantly lower incidence of delirium.
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Authors | Fuhai Ji, Zhongmin Li, Nilas Young, Peter Moore, Hong Liu |
Journal | Journal of cardiothoracic and vascular anesthesia
(J Cardiothorac Vasc Anesth)
Vol. 28
Issue 2
Pg. 267-73
(Apr 2014)
ISSN: 1532-8422 [Electronic] United States |
PMID | 24182835
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier Inc. All rights reserved. |
Chemical References |
- Adrenergic alpha-Agonists
- Dexmedetomidine
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Topics |
- Adrenergic alpha-Agonists
(administration & dosage, therapeutic use)
- Aged
- Cardiac Surgical Procedures
(methods, mortality)
- Cohort Studies
- Coronary Artery Bypass
(methods, mortality)
- Delirium
(epidemiology)
- Dexmedetomidine
(administration & dosage, therapeutic use)
- Electrocardiography
- Female
- Hospital Mortality
- Humans
- Infusions, Intravenous
- Kaplan-Meier Estimate
- Length of Stay
- Logistic Models
- Male
- Middle Aged
- Odds Ratio
- Postoperative Complications
(epidemiology)
- Proportional Hazards Models
- Retrospective Studies
- Risk Factors
- Survival Analysis
- Treatment Outcome
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