Nizatidine Improves Impaired Salivary Secretion in GERD.

Abstract

UNLABELLED:

During esophageal acid clearance, salivation plays an important role in defending the esophageal mucosa. Nizatidine, a histamine H2 receptor antagonist, inhibits acetylcholine esterase, with a resultant increase in acetylcholine. We experienced a patient with gastroesophageal reflux disease (GERD) and impaired salivary secretion who has been successfully treated with nizatidine.

CASE REPORT:

A 63-year-old female visited our hospital with complaints of heartburn and continuous laryngeal discomfort. Saliva scintigraphy was performed to evaluate the salivary function. Washout ratio was decreased to be 25%-40% in individual salivary gland. After the treatment with nizatidine, salivary scintigraphy demonstrated the increased washout ratios. The values of both parotid glands increased up to 90%, whereas those of submandibular glands improved to be around a normal range. GERD symptoms disappeared completely after treatment. In conclusion, nizatidine may be one of therapeutic options for low salivary excretion.

• Authors: Yoshihisa Urita, Toshiyasu Watanabe, Kazuo Hike, Makie Nanami, Tadashi Maeda, Yosuke Sasaki, Asuka Nakayama, Takamasa Ishii, Kaoru Domon, Susumu Ishihara, Masaki Sanaka, Hitoshi Nakajima, Motonobu Sugimoto
• Journal: Clinical medicine. Case reports (Clin Med Case Rep) Vol. 1 Pg. 113-7 ( 2008) ISSN: 1178-6450 [Print] New Zealand
• PMID: 24179359 (Publication Type: Case Reports)