Abstract | OBJECTIVES: DESIGN AND METHODS: This was a retrospective examination of serum markers (peripheral white blood cells, C-reactive Protein and uric acid) and inflammatory markers in the synovial fluid ( lactate, glucose, uric acid, lactate dehydrogenase, synovial fluid white blood cell count, total protein, and interleukin-6) in 53 patients with culture-verified septic arthritis and 29 with gouty arthritis. Receiver-Operating-Characteristic-curves with corresponding Area under the curve (AUC), sensitivity, specificity, likelihood-ratio and interval likelihood-ratios were calculated to define the diagnostic potential of the inflammatory markers. RESULTS: Synovial lactate showed the greatest diagnostic potential (AUC = 0.901, sensitivity = 89.5%, specificity = 77.3%, negative likelihood-ratio = 0.14) followed by synovial glucose (AUC=0.853) and synovial uric acid (AUC = 0.841). CONCLUSIONS:
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Authors | Markus Lenski, Michael A Scherer |
Journal | Clinical biochemistry
(Clin Biochem)
Vol. 47
Issue 1-2
Pg. 49-55
(Jan 2014)
ISSN: 1873-2933 [Electronic] United States |
PMID | 24177196
(Publication Type: Journal Article)
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Copyright | © 2013. |
Chemical References |
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Topics |
- Aged
- Aged, 80 and over
- Arthritis, Gouty
(diagnosis, metabolism)
- Biomarkers
(metabolism)
- Diagnosis, Differential
- Female
- Humans
- Infections
(diagnosis)
- Male
- Middle Aged
- Retrospective Studies
- Synovial Fluid
(metabolism)
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