Abstract | OBJECTIVE: METHODS: RESULTS: Serum amylase, lipase, nitrite, TNF-α, and IL-1β, and pancreatic and lung MPO were increased in both taurolithocholic acid sulfate and cerulein acute pancreatitis compared with the respective control groups. Fucoidan significantly decreased the augmented levels of amylase, lipase, pancreatic and lung MPO, TNF-α, IL-1β, and nitrite in both models. Pancreas histological changes observed in both acute pancreatitis models were significantly attenuated by fucoidan. CONCLUSIONS:
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Authors | Ana C S Carvalho, Rhamon B Sousa, Álvaro Xavier Franco, José Victor Gomes Costa, Luara Manuela Neves, Ronaldo A Ribeiro, Robert Sutton, David N Criddle, Pedro M G Soares, Marcellus H L P de Souza |
Journal | Pancreas
(Pancreas)
Vol. 43
Issue 1
Pg. 82-7
(Jan 2014)
ISSN: 1536-4828 [Electronic] United States |
PMID | 24177139
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Ulcer Agents
- Interleukin-1beta
- Nitrites
- P-Selectin
- Polysaccharides
- Tumor Necrosis Factor-alpha
- L-Selectin
- Taurolithocholic Acid
- Ceruletide
- fucoidan
- Peroxidase
- Lipase
- Amylases
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Topics |
- Acute Disease
- Amylases
(blood)
- Analysis of Variance
- Animals
- Anti-Ulcer Agents
(pharmacology)
- Ceruletide
- Interleukin-1beta
(blood)
- L-Selectin
(metabolism)
- Lipase
(blood)
- Lung
(drug effects, metabolism, pathology)
- Male
- Mice
- Neutrophil Infiltration
(drug effects)
- Nitrites
(blood)
- P-Selectin
(antagonists & inhibitors, metabolism)
- Pancreas
(drug effects, metabolism, pathology)
- Pancreatitis
(blood, chemically induced, prevention & control)
- Peroxidase
(metabolism)
- Polysaccharides
(pharmacology)
- Taurolithocholic Acid
- Tumor Necrosis Factor-alpha
(blood)
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