Immunological profiles determine neurological involvement in Sjögren's syndrome.

Abstract

BACKGROUND:

Up to 68% of patients with primary Sjögren's syndrome (pSS) undergo neurological complications, and evidence for distinct immunological subgroups is emerging. We sought to determine systemic and immunological profiles associated with neurological manifestations.

METHODS:

420 patients fulfilling the 2002 American-European pSS criteria were retrospectively analyzed. Neurological manifestations were diagnosed through clinical, biological, electrophysiological, and imaging findings. Biographical, clinical, and laboratory data were compared.

RESULTS:

Within 93 (22%) patients with neurological manifestations, peripheral and central nervous systems were involved in 66% and 44%, respectively. Raynaud's phenomenon, cutaneous vasculitis, renal involvement, and cryoglobulinemia were associated with sensorimotor neuropathy and mononeuritis multiplex (p<0.05). Conversely, pure sensory neuropathy occurred without extraglandular manifestation, and without anti-Ro/SSA antibodies (p<0.05). All neurological manifestations were associated with increased use of corticosteroids and immunosuppressive drugs (p<0.05).

CONCLUSIONS:

In pSS, patients with sensorimotor neuropathies and pure sensory neuropathies have distinct extraglandular and immunological profiles.

• Authors: Yvan Jamilloux, Laurent Magy, Jean-François Hurtevent, Guillaume Gondran, Jérôme de Seze, David Launay, Kim H Ly, Marc Lambert, Eric Hachulla, Pierre-Yves Hatron, Elisabeth Vidal, Anne-Laure Fauchais
• Journal: European journal of internal medicine (Eur J Intern Med) Vol. 25 Issue 2 Pg. 177-81 (Feb 2014) ISSN: 1879-0828 [Electronic] Netherlands
• PMID: 24176941 (Publication Type: Journal Article)
• Copyright: © 2013.

Chemical References

• Antibodies, Antinuclear
• SS-A antibodies
• SS-B antibodies
• Rheumatoid Factor

Topics

• Adult
• Aged
• Antibodies, Antinuclear (immunology)
• Central Nervous System Diseases (etiology, immunology)
• Cohort Studies
• Cryoglobulinemia
• Female
• Humans
• Kidney Diseases (etiology, immunology)
• Male
• Middle Aged
• Mononeuropathies (etiology, immunology)
• Motor Neuron Disease (etiology, immunology)
• Peripheral Nervous System Diseases (etiology, immunology)
• Polyradiculopathy (etiology, immunology)
• Proportional Hazards Models
• Raynaud Disease (etiology, immunology)
• Retrospective Studies
• Rheumatoid Factor (immunology)
• Sjogren's Syndrome (complications, immunology, physiopathology)
• Somatosensory Disorders (etiology, immunology)
• Vasculitis (etiology, immunology)