Abstract |
The efficacy of N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP), 6-O-stearoyl-MDP (L18-MDP), N alpha-acetylmuramyl-L-alanyl-D-isoglutaminyl-N epsilon-stearoyl- L-lysine (MDP-Lys-L18) and N-stearoylmuramyl-L-alanyl-D- isoglutamine (2N-L18-MDP) for augmenting host-resistance to viral infection was examined in Sendai virus infected mice. L18-MDP and MDP-Lys-L18 augmented the non-specific host-resistance to infection with Sendai virus. MDP showed a slight enhancement of host-resistance to this infection but 2N-L18-MDP was ineffective. The protective effect of MDP-Lys-L18 was seen only when the drug was administered a few days before the virus challenge. The intranasal administration of MDP-Lys-L18 was effective at 1 microgram but only slight activity was observed in mice treated intravenously or intraperitoneally even at the 100 microgram dose level. MDP-Lys-L18 treatment preceding infection augmented interferon production in the lung of the mice but MDP-Lys-L18 treatment alone induced no interferon.
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Authors | C Ishihara, N Hamada, K Yamamoto, J Iida, I Azuma, Y Yamamura |
Journal | Vaccine
(Vaccine)
Vol. 3
Issue 5
Pg. 370-4
(Dec 1985)
ISSN: 0264-410X [Print] Netherlands |
PMID | 2417426
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Interferon Inducers
- Acetylmuramyl-Alanyl-Isoglutamine
- Interferons
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Topics |
- Acetylmuramyl-Alanyl-Isoglutamine
(administration & dosage, analogs & derivatives, therapeutic use)
- Administration, Intranasal
- Animals
- Immunity, Active
- Immunity, Innate
- Injections, Intraperitoneal
- Injections, Intravenous
- Interferon Inducers
- Interferons
(biosynthesis)
- Lung
(drug effects, immunology)
- Male
- Mice
- Mice, Inbred BALB C
- Parainfluenza Virus 1, Human
(immunology)
- Paramyxoviridae Infections
(immunology)
- Structure-Activity Relationship
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