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Effect of muramyl dipeptide and its stearoyl derivatives on resistance to Sendai virus infection in mice.

Abstract
The efficacy of N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP), 6-O-stearoyl-MDP (L18-MDP), N alpha-acetylmuramyl-L-alanyl-D-isoglutaminyl-N epsilon-stearoyl-L-lysine (MDP-Lys-L18) and N-stearoylmuramyl-L-alanyl-D-isoglutamine (2N-L18-MDP) for augmenting host-resistance to viral infection was examined in Sendai virus infected mice. L18-MDP and MDP-Lys-L18 augmented the non-specific host-resistance to infection with Sendai virus. MDP showed a slight enhancement of host-resistance to this infection but 2N-L18-MDP was ineffective. The protective effect of MDP-Lys-L18 was seen only when the drug was administered a few days before the virus challenge. The intranasal administration of MDP-Lys-L18 was effective at 1 microgram but only slight activity was observed in mice treated intravenously or intraperitoneally even at the 100 microgram dose level. MDP-Lys-L18 treatment preceding infection augmented interferon production in the lung of the mice but MDP-Lys-L18 treatment alone induced no interferon.
AuthorsC Ishihara, N Hamada, K Yamamoto, J Iida, I Azuma, Y Yamamura
JournalVaccine (Vaccine) Vol. 3 Issue 5 Pg. 370-4 (Dec 1985) ISSN: 0264-410X [Print] Netherlands
PMID2417426 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Interferon Inducers
  • Acetylmuramyl-Alanyl-Isoglutamine
  • Interferons
Topics
  • Acetylmuramyl-Alanyl-Isoglutamine (administration & dosage, analogs & derivatives, therapeutic use)
  • Administration, Intranasal
  • Animals
  • Immunity, Active
  • Immunity, Innate
  • Injections, Intraperitoneal
  • Injections, Intravenous
  • Interferon Inducers
  • Interferons (biosynthesis)
  • Lung (drug effects, immunology)
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Parainfluenza Virus 1, Human (immunology)
  • Paramyxoviridae Infections (immunology)
  • Structure-Activity Relationship

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