Association of vitamin D status and blood pressure response after renal denervation.

Abstract

BACKGROUND:

Vitamin D deficiency is associated with hypertension; however, it is unclear whether vitamin D influences therapeutic blood pressure reduction. Renal sympathetic denervation (RDN) reduces blood pressure in resistant hypertension. We hypothesized that vitamin D might influence blood pressure response to RDN.

METHODS:

Vitamin D was measured in 101 patients with resistant hypertension undergoing RDN. The associations between vitamin D status and systolic blood pressure (SBP) reduction 6 months after RDN were analyzed.

RESULTS:

Mean office SBP at baseline was 171.5 ± 2 mmHg. After RDN, mean office SBP was reduced by 28.4 ± 2.3 mmHg (p = 0.007). 85 patients (84.2 %) had SBP reductions >10 mmHg (responders). Vitamin D concentrations were lower in non-responders as compared to responders (9.9 ± 4.5 vs. 13.7 ± 7.4 ng/ml, p = 0.008). Non-responders (n = 16, 15.8 %), more often had a vitamin D concentration below the median as compared to responders (81 vs. 46 %, p = 0.013). The percentage of patients with normal vitamin D concentrations increased with increasing tertiles of SBP reduction (p for trend = 0.020). In patients with vitamin D concentrations below the median, SBP reduction was lower as compared to patients with a vitamin D concentration above the median (23.5 ± 3.2 vs. 33.7 ± 3.2 mmHg, p = 0.026). Baseline vitamin D concentrations correlated with SBP reduction (r = 0.202, p = 0.043).

CONCLUSIONS:

In patients with resistant hypertension, low vitamin D concentrations were associated with a decreased SBP response and a higher rate of non-response.

• Authors: Janine Pöss, Felix Mahfoud, Christian Ukena, Murray David Esler, Markus Schlaich, Dagmara Hering, Bodo Cremers, Ulrich Laufs, Michael Böhm
• Journal: Clinical research in cardiology : official journal of the German Cardiac Society (Clin Res Cardiol) Vol. 103 Issue 1 Pg. 41-7 (Jan 2014) ISSN: 1861-0692 [Electronic] Germany
• PMID: 24173883 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antihypertensive Agents
• Biomarkers
• Vitamin D
• 25-hydroxyvitamin D

Topics

• Antihypertensive Agents (therapeutic use)
• Autonomic Denervation
• Biomarkers (blood)
• Blood Pressure (drug effects)
• Cross-Sectional Studies
• Drug Resistance
• Female
• Humans
• Hypertension (complications, diagnosis, physiopathology, therapy)
• Kidney (innervation)
• Male
• Middle Aged
• Time Factors
• Treatment Outcome
• Vitamin D (analogs & derivatives, blood)
• Vitamin D Deficiency (blood, complications, diagnosis)