Human cellular immune response to copolymer I and myelin basic protein.

Abstract

Copolymer I (Cop I) is being tested as a treatment for MS because it protects animals against experimental allergic encephalomyelitis, and because there is immunologic cross-reactivity reported between Cop I and myelin basic protein (MBP). From the peripheral blood mononuclear cells of four normal individuals, we isolated helper-phenotype T-cell lines that reacted in vitro with Cop I or MBP. Cop I-reactive cell lines did not respond to MBP, nor did MBP-reactive T-cell lines respond to Cop I. Antigen-specific immune tolerance was induced in MBP-reactive cell lines by exposure to MBP in vitro, but similar exposure to Cop I did not induce tolerance in the MBP-reactive cell lines. We found no evidence of immunologic cross-reactivity between Cop I and MBP.

• Authors: J Burns, L J Krasner, F Guerrero
• Journal: Neurology (Neurology) Vol. 36 Issue 1 Pg. 92-4 (Jan 1986) ISSN: 0028-3878 [Print] United States
• PMID: 2417162 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Myelin Basic Protein
• Peptides
• (T,G)-A-L

Topics

• Animals
• Antibody Formation
• Cell Line
• Cross Reactions
• Female
• Guinea Pigs
• Humans
• Immune Tolerance
• Immunity, Cellular
• Lymphocytes (embryology)
• Male
• Myelin Basic Protein (immunology)
• Peptides (immunology)
• Phenotype
• T-Lymphocytes (immunology, physiology)