Abstract | OBJECTIVE: METHODS: Among a total of 2642 pathologically diagnosed EOC cases, 21 cases with SMJN were histopathologically diagnosed and had an age range of 40-66 years at Sun Yat-sen University Cancer Center between January 1991 and January 2011. Their clinical data were retrospectively analyzed. RESULTS: The incidence of SMJN in EOC was 0.79 %. The 1, 2 and 5-year survival rates were 61.8%, 26.8% and 9.5% respectively. The diagnosis was confirmed via local excision biopsy, fine-needle aspiration biopsy or gross pathological diagnosis. Univariate analysis showed that patients with progressive disease or relapsing with umbilical metastasis after treatment had worse prognosis than those diagnosed at pre-treatment (22 vs 6 months, P < 0.01) . Patients with suboptimal cytoreductive surgery and/or less than 6 circles of chemotherapy or palliative treatment had worse prognosis than those with optional cytoreductive surgery during 6-8 circles of chemotherapy (21 vs. 4 months). Multivariate analysis showed that the time to diagnose and treatment regimen were independent predictors of survival (relative risk = 41.28, P < 0.01). CONCLUSIONS: SMJN is a rare manifestation of EOC. Improving the diagnostic vigilance, optimal debulking surgery plus regular chemotherapy and other new individualized postoperative treatments may arrest the progression of EOC and prolong patient survival.
|
Authors | Juan Xiao, Jun-dong Li, Man-man Xu, An-na Zhu, Yan-lin Feng |
Journal | Zhonghua yi xue za zhi
(Zhonghua Yi Xue Za Zhi)
Vol. 93
Issue 25
Pg. 1986-8
(Jul 02 2013)
ISSN: 0376-2491 [Print] China |
PMID | 24169250
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Topics |
- Adult
- Aged
- Carcinoma, Ovarian Epithelial
- Female
- Humans
- Middle Aged
- Neoplasm Metastasis
- Neoplasms, Glandular and Epithelial
(diagnosis, pathology)
- Ovarian Neoplasms
(diagnosis, pathology)
- Prognosis
- Retrospective Studies
- Umbilicus
(pathology)
|