Anti-yo associated paraneoplastic cerebellar degeneration in a man with large cell cancer of the lung.

Abstract

Purkinje cell cytoplasmic antibody type 1 (PCA-1), or anti-Yo, is the most frequently detected autoantibody in paraneoplastic cerebellar degeneration (PCD). The vast majority of cases of anti-Yo PCD, however, occur in females over 60 years old and are associated with gynecologic tumors. Only 10 cases have been reported in males, and only 2 were associated with cancer of the lung. Here we describe the youngest known case of PCA-1 positive PCD in a male, whose lung tumor was undetectable even on FDG-PET.

• Authors: Linda Hasadsri, James Lee, Bonnie H Wang, Lalitha Yekkirala, Mingtao Wang
• Journal: Case reports in neurological medicine (Case Rep Neurol Med) Vol. 2013 Pg. 725936 ( 2013) ISSN: 2090-6668 [Print] United States
• PMID: 24167748 (Publication Type: Journal Article)