A systematic review of Gymnema sylvestre in obesity and diabetes management.

Abstract

The prevalence of obesity is associated with many health-related problems. Currently, more than 300 million people are considered to be obese. According to the World Health Organization (WHO), by 2030, 87 and 439 million people will be affected in India and the world, respectively. Today, herbal medicines are gaining interest in the treatment of obesity and diabetes, because of their minimal side effects. Gymnemic acid - an active component isolated from Gymnema sylvestre - has anti-obesity and antidiabetic properties, decreases body weight and also inhibits glucose absorption. Several components extracted from Gymnema prevent the accumulation of triglycerides in muscle and liver, and also decrease fatty acid accumulation in the circulation. In this paper, an attempt has been made to review the effects of various extracts from Gymnema sylvestre in the regulation of carbohydrate and lipid metabolism in both animal and clinical studies.

• Authors: Ramesh Pothuraju, Raj Kumar Sharma, Jayasimha Chagalamarri, Surender Jangra, Praveen Kumar Kavadi
• Journal: Journal of the science of food and agriculture (J Sci Food Agric) Vol. 94 Issue 5 Pg. 834-40 (Mar 30 2014) ISSN: 1097-0010 [Electronic] England
• PMID: 24166097 (Publication Type: Comparative Study, Journal Article, Review, Systematic Review)
• Copyright: © 2013 Society of Chemical Industry.

Chemical References

• Anti-Obesity Agents
• Dietary Sucrose
• Hypoglycemic Agents
• Lipotropic Agents
• Plant Extracts
• Saponins
• Solvents
• Triterpenes
• gymnemic acid

Topics

• Animals
• Anti-Obesity Agents (adverse effects, chemistry, isolation & purification, therapeutic use)
• Diabetes Mellitus, Type 2 (diet therapy, drug therapy, metabolism)
• Dietary Sucrose (antagonists & inhibitors, metabolism)
• Dietary Supplements (adverse effects, analysis)
• Gymnema sylvestre (chemistry)
• Humans
• Hypoglycemic Agents (adverse effects, chemistry, isolation & purification, therapeutic use)
• Intestinal Absorption (drug effects)
• Lipid Metabolism (drug effects)
• Lipotropic Agents (adverse effects, chemistry, isolation & purification, therapeutic use)
• Obesity (diet therapy, drug therapy, metabolism)
• Plant Extracts (adverse effects, chemistry, isolation & purification, therapeutic use)
• Plant Leaves (chemistry)
• Saponins (adverse effects, analysis, therapeutic use)
• Solvents (chemistry)
• Triterpenes (adverse effects, analysis, therapeutic use)
• Weight Loss (drug effects)