Extended spectrum β-lactamase-producing Enterobacteriaceae infection in heart and lung transplant recipients and in mechanical circulatory support recipients.

Abstract

BACKGROUND:

Extended spectrum β-lactamase (ESBL)-producing gram-negative bacilli are increasingly reported in patients with a variety of risk factors including prior cephalosporin and antibiotic usage, prolonged hospitalizations, existence of comorbid conditions, and critical illness.

METHODS:

Retrospective review of infections caused by ESBL-producing Enterobacteriaceae was performed in heart transplant (HTx), lung transplant (LTx), and mechanical circulatory support (MCS) device recipients at a large transplant center.

RESULTS:

Among 1065 patients transplanted/implanted, the incidence of ESBL-related infections (bacteremia, urinary tract infections, pneumonia, central venous catheter-associated infection, and wound infections) in HTx, LTx, and MCS device recipients was reported at 2.2%, 5.5%, and 10.7%, respectively, caused by ESBL-producing Klebsiella pneumoniae, Escherichia coli, Klebsiella oxytoca, and Citrobacter freundii.

CONCLUSIONS:

Early detection and adequate duration of therapy for ESBL-producing Enterobacteriaceae in solid organ transplants and MCS device recipients are essential in successful patient outcomes including prevention of recurrent infection.

• Authors: Kevin T Bui, Seema Mehta, Tam H Khuu, David Ross, Margrit Carlson, Matthew R Leibowitz, Joanna M Schaenman, Rajan Saggar, Joseph P Lynch 3rd, Abbas Ardehali, Bernard M Kubak
• Journal: Transplantation (Transplantation) Vol. 97 Issue 5 Pg. 590-4 (Mar 15 2014) ISSN: 1534-6080 [Electronic] United States
• PMID: 24162251 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• beta-Lactamases

Topics

• Adult
• Aged
• Enterobacteriaceae (metabolism)
• Enterobacteriaceae Infections (epidemiology, mortality)
• Escherichia coli Infections (epidemiology, mortality)
• Female
• Heart Transplantation (statistics & numerical data)
• Heart-Assist Devices (statistics & numerical data)
• Humans
• Incidence
• Klebsiella Infections (epidemiology, mortality)
• Lung Transplantation (statistics & numerical data)
• Male
• Middle Aged
• Retrospective Studies
• Survival Rate
• Time Factors
• Transplantation (statistics & numerical data)
• beta-Lactamases (metabolism)