Abstract | OBJECTIVES: BACKGROUND: It is still unclear if patients treated for ISR may benefit from a long DAPT regimen. METHODS: For the present purpose, we selected 224 patients undergoing the PCI procedure for ISR enrolled in the PRODIGY (Prolonging Dual Antiplatelet Treatment After Grading Stent-Induced Intimal Hyperplasia) trial and randomized to short (6 months) versus long (24 months) DAPT regimen. The primary objective was the cumulative incidence of death, nonfatal myocardial infarction (MI), or cerebrovascular accident at 24 months. Safety endpoints were moderate and major bleeding complications. RESULTS: Overall, 114 patients were allocated to short DAPT regimen, whereas 110 patients were allocated to long DAPT regimen. Twenty-seven patients reached the primary endpoint (19 in short DAPT regimen vs. 8 in long DAPT regimen; p = 0.02). The cumulative incidence of the primary endpoint at 24 months was 16.7% in the short DAPT regimen group compared with 7.3% in the long DAPT regimen group (p = 0.034). This is principally due to a lower occurrence of death and MI in the long DAPT regimen group as compared to the short DAPT regimen group (6.5% vs. 15.5%; p = 0.03). There was no difference in the occurrence of bleeding complications between long and short DAPT regimen. CONCLUSIONS:
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Authors | Gianluca Campo, Matteo Tebaldi, Pascal Vranckx, Simone Biscaglia, Carlo Tumscitz, Roberto Ferrari, Marco Valgimigli |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 63
Issue 6
Pg. 506-12
(Feb 18 2014)
ISSN: 1558-3597 [Electronic] United States |
PMID | 24161321
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)
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Copyright | Copyright © 2014 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Platelet Aggregation Inhibitors
- Clopidogrel
- Ticlopidine
- Aspirin
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Topics |
- Aged
- Aged, 80 and over
- Aspirin
(administration & dosage)
- Clopidogrel
- Coronary Restenosis
(complications, mortality, therapy)
- Female
- Humans
- Italy
(epidemiology)
- Male
- Middle Aged
- Myocardial Infarction
(epidemiology, etiology, prevention & control)
- Percutaneous Coronary Intervention
- Platelet Aggregation Inhibitors
(administration & dosage)
- Postoperative Complications
(epidemiology, etiology, prevention & control)
- Stroke
(epidemiology, etiology, prevention & control)
- Ticlopidine
(administration & dosage, analogs & derivatives)
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