Introduction. Operative blood loss is still a great obstacle to liver resection, and various topical
hemostatic agents were introduced to reduce it. The aim of the current study is to evaluate effects of 3 different types of these agents. Methods. In this randomized clinical trial, 45 patients undergoing liver resection were assigned to receive
TachoSil,
Surgicel, and
Glubran 2 for controlling
bleeding. Intraoperative and postoperative findings were compared between groups. Results. Postoperative
bleeding (0 versus 33.3%, P = 0.04) and drainage volume first day after surgery (281.33 ± 103.98 versus 150.00 ± 60.82 mL, P = 0.02) were significantly higher in
Surgicel than in
TachoSil group. Postoperative complications included bile leak (3 cases in
Surgicel, 1 case in
TachoSil and
Glubran 2), noninfectious collection (2 cases in
TachoSil and
Surgicel and 1 case in
Glubran 2), perihepatic
abscess, and massive
hematoma around
hepatectomy site both in
Surgicel group. There was no death during the study period. Conclusion. Due to higher complications in
Surgicel group, its application as
hemostatic agent after liver resection is not recommended. Better results in
TachoSil in comparison to the other two are indicative of its better efficacy and superiority in controlling hemostasis.