Gnawing at Metchnikoff's paradigm.

Abstract

In this issue of Blood, Rossi et al provide convincing evidence that extends and generalizes the importance of trogocytosis, a process in which effector cells use Fcg receptors to remove Immunoglobulin G (IgG)-chelated antigens from donor cells. Their work suggests that the process may be beneficial in the context of epratuzumab treatment of autoimmune diseases.

• Authors: Ronald P Taylor
• Journal: Blood (Blood) Vol. 122 Issue 17 Pg. 2922-4 (Oct 24 2013) ISSN: 1528-0020 [Electronic] United States
• PMID: 24159161 (Publication Type: Journal Article, Comment)

Chemical References

• Antibodies, Monoclonal, Humanized
• Antineoplastic Agents
• CD22 protein, human
• Sialic Acid Binding Ig-like Lectin 2
• epratuzumab

Topics

• Antibodies, Monoclonal, Humanized (pharmacology)
• Antineoplastic Agents (pharmacology)
• B-Lymphocytes (drug effects)
• Humans
• Lupus Erythematosus, Systemic (drug therapy)
• Lymphoma, Non-Hodgkin (drug therapy)
• Phagocytosis (drug effects)
• Sialic Acid Binding Ig-like Lectin 2 (immunology)