Abstract | RATIONALE:
Obstructive sleep apnea (OSA) is associated with cardiovascular morbidity and mortality, although the underlying mechanisms are not well understood. OBJECTIVES: We aimed to determine whether more severe OSA, measured by the Respiratory Disturbance Index (RDI), is associated with subclinical myocardial injury and increased myocardial wall stress. METHODS: MEASUREMENTS AND MAIN RESULTS: OSA severity was defined using conventional clinical categories: none (RDI ≤ 5), mild (RDI 5-15), moderate (RDI 15-30), and severe (RDI > 30). Hs- TnT, but not NT-proBNP, was associated with OSA after adjusting for 17 potential confounders (P = 0.02). Over a median of 12.4 (interquartile range, 11.6-13.1) years follow-up, hs- TnT was related to risk of death or incident heart failure in all OSA categories (P ≤ 0.05 in each category). CONCLUSIONS: In middle-aged to older individuals, OSA severity is independently associated with higher levels of hs- TnT, suggesting that subclinical myocardial injury may play a role in the association between OSA and risk of heart failure. OSA was not associated with NT-proBNP levels after adjusting for multiple possible confounders.
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Authors | Gabriela Querejeta Roca, Susan Redline, Naresh Punjabi, Brian Claggett, Christie M Ballantyne, Scott D Solomon, Amil M Shah |
Journal | American journal of respiratory and critical care medicine
(Am J Respir Crit Care Med)
Vol. 188
Issue 12
Pg. 1460-5
(Dec 15 2013)
ISSN: 1535-4970 [Electronic] United States |
PMID | 24156237
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Biomarkers
- Peptide Fragments
- Troponin T
- pro-brain natriuretic peptide (1-76)
- Natriuretic Peptide, Brain
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Topics |
- Aged
- Asymptomatic Diseases
- Biomarkers
(blood)
- Cardiomyopathies
(blood, diagnosis, etiology)
- Cross-Sectional Studies
- Female
- Humans
- Linear Models
- Male
- Middle Aged
- Natriuretic Peptide, Brain
(blood)
- Peptide Fragments
(blood)
- Polysomnography
- Proportional Hazards Models
- Risk Factors
- Severity of Illness Index
- Sleep Apnea, Obstructive
(blood, complications, diagnosis)
- Troponin T
(blood)
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