Hypolipidemic and antioxidant properties of phenolic compound-rich extracts from white ginseng (Panax ginseng) in cholesterol-fed rabbits.

Abstract

In this study, the effect of low-molecular weight white ginseng compounds on various biochemical indices, including blood lipid concentrations and antioxidant enzyme activities and morphological changes was investigated in rabbits with high cholesterol diet-induced hypercholesterolemia. The experimental animals were 16-week-old male New Zealand white rabbits divided into normal control diet, high cholesterol diet, and high cholesterol with 0.05% white ginseng low-molecule compound groups, treated for 4 weeks. Blood lipid concentrations were higher in the high cholesterol groups compared to the normal control group but were not improved by the white ginseng low-molecular weight compound. We note however that antioxidant enzyme activities and morphological changes of the aorta showed that white ginseng small compounds had a positive effect on hypercholesterolemia. Based on such results, low-molecular weight compounds rich in phenolic compounds in white ginseng can be said to be effective in part in improving hyperlipidemia and atherosclerosis induced by a high cholesterol diet among New Zealand white rabbits.

• Authors: Lan-Sook Lee, Chang-Won Cho, Hee-Do Hong, Young-Chul Lee, Ung-Kyu Choi, Young-Chan Kim
• Journal: Molecules (Basel, Switzerland) (Molecules) Vol. 18 Issue 10 Pg. 12548-60 (Oct 10 2013) ISSN: 1420-3049 [Electronic] Switzerland
• PMID: 24152674 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anticholesteremic Agents
• Antioxidants
• Cholesterol, Dietary
• Lipids
• Phenols
• Plant Extracts
• Catalase
• Glutathione Peroxidase
• Superoxide Dismutase
• Glutathione Transferase

Topics

• Animals
• Anticholesteremic Agents (isolation & purification, pharmacology, therapeutic use)
• Antioxidants (isolation & purification, pharmacology, therapeutic use)
• Aorta (drug effects, pathology)
• Atherosclerosis (drug therapy, etiology, pathology)
• Catalase (metabolism)
• Cholesterol, Dietary (administration & dosage)
• Glutathione Peroxidase (metabolism)
• Glutathione Transferase (metabolism)
• Hypercholesterolemia (blood, drug therapy, etiology)
• Lipid Peroxidation (drug effects)
• Lipids (blood)
• Liver (drug effects, enzymology)
• Male
• Panax (chemistry)
• Phenols (isolation & purification, pharmacology, therapeutic use)
• Plant Extracts (isolation & purification, pharmacology, therapeutic use)
• Rabbits
• Superoxide Dismutase (metabolism)