Abstract | BACKGROUND:
Decorin is an extracellular matrix, multifunctional small proteoglycan molecule in tumor stroma that has been shown to be modulator of angiogenesis. No clinical data is available so far on decorin expression and survival outcome of oral cancer. AIM: MATERIALS AND METHODS: RESULTS: Cytoplasmic staining of decorin was observed in the basal layer of epithelium in 53 (73.61%) cases of PMOLs and in peritumoral stroma in 55 (50.92%) cases of OSCC. None of the cases showed nuclear expression of decorin. Decorin expression both at phenotypic and molecular level was found to be down-regulated from PMOLs to OSCC. Lymph node metastasis and reduced decorin expression independently correlated with overall survival in OSCC. VEGF-A expression had no significant impact on survival outcome. CONCLUSION: Micro vessel density and VEGF-A expression were significantly associated with reduced decorin expression in tumor stroma suggesting, decorin as angiogenic modulator in OSCC. Down-regulation of decorin expression and the presence of lymph node metastasis were adverse factor independently affecting overall survival in OSCC.
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Authors | Seema Nayak, Madhu Mati Goel, Vikram Bhatia, Saumya Chandra, Annu Makker, Sandeep Kumar, Satya Prakash Agrawal, Divya Mehrotra, Srikanta Kumar Rath |
Journal | Indian journal of pathology & microbiology
(Indian J Pathol Microbiol)
2013 Jul-Sep
Vol. 56
Issue 3
Pg. 204-10
ISSN: 0974-5130 [Electronic] India |
PMID | 24152495
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- DCN protein, human
- Decorin
- RNA, Messenger
- VEGFA protein, human
- Vascular Endothelial Growth Factor A
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Topics |
- Adult
- Biopsy
- Carcinoma, Squamous Cell
(mortality, pathology)
- Decorin
(biosynthesis, genetics)
- Female
- Fibrosis
(pathology)
- Gene Expression Profiling
- Humans
- Immunohistochemistry
- Leukoplakia
(pathology)
- Male
- Middle Aged
- Mouth Neoplasms
(mortality, pathology)
- Neovascularization, Pathologic
- RNA, Messenger
(analysis, genetics)
- Real-Time Polymerase Chain Reaction
- Survival Analysis
- Vascular Endothelial Growth Factor A
(biosynthesis, genetics)
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