Abstract |
In a randomized trial, 55 patients with acute external otitis were treated with either topical framycitin/ gramicidin ( Sofradex) or oxytetracycline/ hydrocortisone ( Terracortril) with polymyxin B (TPB) ear-drops for 1 week. Staphylococcus aureus and Pseudomonas pyocyanea were the bacteria most frequently found in the ear canal; 78% of the patients were cured. However, no significant differences in therapy were found when either of the preparations was used. S. aureus seemed to be most resistant to treatment, while P. pyocyanea was less of a therapeutic problem. Additionally, previous episodes of external otitis or other skin diseases did not seem to influence any treatment given.
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Authors | C J Wadsten, C A Bertilsson, H Sieradzki, S Edström |
Journal | Archives of oto-rhino-laryngology
(Arch Otorhinolaryngol)
Vol. 242
Issue 2
Pg. 135-9
( 1985)
ISSN: 0302-9530 [Print] Germany |
PMID | 2415098
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anti-Inflammatory Agents
- Drug Combinations
- Polymyxins
- Gramicidin
- Framycetin
- Sofradex
- Dexamethasone
- Polymyxin B
- Hydrocortisone
- Oxytetracycline
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Topics |
- Administration, Topical
- Adolescent
- Adult
- Aged
- Anti-Inflammatory Agents
(administration & dosage)
- Bacterial Infections
(drug therapy)
- Child
- Clinical Trials as Topic
- Dexamethasone
(administration & dosage)
- Drug Combinations
(administration & dosage)
- Ear Canal
(microbiology)
- Female
- Framycetin
(administration & dosage)
- Gramicidin
(administration & dosage)
- Humans
- Hydrocortisone
- Male
- Middle Aged
- Otitis Externa
(drug therapy, microbiology)
- Oxytetracycline
(administration & dosage)
- Polymyxin B
(administration & dosage)
- Polymyxins
(administration & dosage)
- Pseudomonas
(isolation & purification)
- Random Allocation
- Staphylococcus aureus
(isolation & purification)
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