[Occupational acute dimethylformamide poisoning: an analysis of 16 cases].

Abstract

OBJECTIVE:

To analyze the clinical features and diagnostic points of occupational acute dimethylformamide (DMF) poisoning and to explore the mechanism of occupational acute DMF poisoning.

METHODS:

A comprehensive analysis was performed on the clinical data of 16 cases of occupational acute DMF poisoning, including symptoms, signs, and laboratory testing results.

RESULTS:

The main clinical features of occupational acute DMF poisoning were digestive system impairments, especially abdominalgia. Hemorrhagic gastroenteritis was not found by gastroscopy. There was no significant correlation between the degree of abdominalgia and alanine aminotransferase level (r(s) = 0.109, P>0.05).

CONCLUSION:

Abdominalgia is recommended to be one of the reference indices for the diagnosis and degrading of occupational acute DMF poisoning, The mechanism of DMF poisoning remains unclear but it is considered to be related to methyl isocyanate, the intermediate product of DMF metabolism.

• Authors: Peng Wang, Jian-shu Huang, Xiu-ju Li, Li Ma, Yuan-ling Zhou, Peng-qin Liao, Li-hua Wang
• Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases (Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi) Vol. 31 Issue 10 Pg. 765-7 (Oct 2013) ISSN: 1001-9391 [Print] China
• PMID: 24148956 (Publication Type: English Abstract, Journal Article)

Chemical References

• Solvents
• Dimethylformamide
• Alanine Transaminase

Topics

• Abdominal Pain (chemically induced)
• Alanine Transaminase (metabolism)
• Dimethylformamide (poisoning)
• Humans
• Occupational Exposure
• Solvents (poisoning)