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FELD better not thinking of metastases only when liver lesions appear after bleomycin-based treatment for non-seminoma testis from metastases.

AbstractBACKGROUND:
Bleomycin has become an integral part of chemotherapy in patients with germ-cell tumors. One of the most feared side effects is bleomycin-induced pneumonitis. In patients with mild or moderate BIP, radiological signs disappear almost completely within nine months after discontinuation of bleomycin treatment.
CASE PRESENTATION:
We present a patient with a history of non seminoma of the testis and bleomycin-induced pneumonitis. During follow-up, regression of the hypothesis of eosinophilic migration to the liver after regression of bleomycin-induced pneumonitis is highly suspicious based on transient eosinophilia and focal eosinophilic liver disease.
CONCLUSION:
As follow up may consist of CT scanning in germ-line tumor patients, transient eosinophilic liver lesions reported during regressive bleomycin-induced pneumonitis should not be presumed automatically as metastatic tumor relapse and require further sequential imaging and pathological examination.
AuthorsFilip Y F L De Vos, Sasja F Mulder, Joost P H Drenth, Iris D Nagtegaal, Jurgen J Fütterer, Winette T A van der Graaf
JournalBMC cancer (BMC Cancer) Vol. 13 Pg. 491 (Oct 22 2013) ISSN: 1471-2407 [Electronic] England
PMID24148527 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antibiotics, Antineoplastic
  • Bleomycin
Topics
  • Adult
  • Antibiotics, Antineoplastic (adverse effects, therapeutic use)
  • Bleomycin (adverse effects, therapeutic use)
  • Chemical and Drug Induced Liver Injury (diagnosis, pathology)
  • Eosinophilia (chemically induced)
  • Humans
  • Lymphocytes (pathology)
  • Magnetic Resonance Imaging
  • Male
  • Neoplasm Staging
  • Testicular Neoplasms (complications, drug therapy, pathology)
  • Tomography, X-Ray Computed

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