Paraneoplastic cerebellar degeneration caused by ovarian clear-cell carcinoma.

Abstract

Paraneoplastic cerebellar degeneration is a paraneoplastic neurological syndrome caused by the remote effect of certain systemic cancers and is characterized by subacute cerebellar symptoms. A 62-year-old woman suffering from unidentified cerebellar symptoms was admitted to our hospital. Paraneoplastic cerebellar degeneration was suspected and ovarian cancer was detected after the systemic examination for malignancy. The symptoms of vertigo and dysarthria were improved a little after surgical operation and treatments of γ-globulin, steroid pulse and tacrolimus hydrate. The cerebellar symptoms of paraneoplastic cerebellar degeneration are often evident prior to detection of malignancy. It is important to perform systemic examination for malignancy in case of unidentified cerebellar symptoms.

• Authors: Y Negishi, K Sakai, Y Noguchi, N Iwasaki, N Kawai
• Journal: The journal of obstetrics and gynaecology research (J Obstet Gynaecol Res) Vol. 40 Issue 2 Pg. 614-7 (Feb 2014) ISSN: 1447-0756 [Electronic] Australia
• PMID: 24148073 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2013 The Authors. Journal of Obstetrics and Gynaecology Research © 2013 Japan Society of Obstetrics and Gynecology.

Chemical References

• Antibodies
• CDR2 protein, human
• Nerve Tissue Proteins

Topics

• Adenocarcinoma, Clear Cell (complications, diagnosis)
• Antibodies (blood)
• Female
• Humans
• Middle Aged
• Nerve Tissue Proteins (immunology)
• Ovarian Neoplasms (complications, diagnosis)
• Paraneoplastic Cerebellar Degeneration (blood, etiology)