Effect of risedronate on speed of sound in postmenopausal women with osteoporosis.

Abstract

AIM:

To examine the effects of treatment with risedronate for 1 year on speed of sound (SOS) of the calcaneus and bone turnover markers in postmenopausal women with osteoporosis.

METHODS:

Thirty-eight postmenopausal women with osteoporosis who had been treated with risedronate for > 1 year were enrolled in the study. The SOS and bone turnover markers were monitored during treatment with risedronate for 1 year.

RESULTS:

The urinary levels of cross-linked N-terminal telopeptides of type I collagen and serum levels of alkaline phosphatase were significantly decreased at 3 mo (-34.7%) and 12 mo (-21.2%), respectively, compared with the baseline values. The SOS increased modestly, but significantly by 0.65% at 12 mo compared with the baseline value. Treatment with risedronate elicited an increase in the SOS of the calcaneus exceeding the coefficient of variation in vivo (0.27%).

CONCLUSION:

The present study confirmed that risedronate suppressed bone turnover and elicited a clinically significant increase in the SOS of the calcaneus in postmenopausal women with osteoporosis.

• Authors: Jun Iwamoto, Tetsuya Takada, Yoshihiro Sato, Hideo Matsumoto
• Journal: World journal of orthopedics (World J Orthop) Vol. 4 Issue 4 Pg. 316-22 ( 2013) ISSN: 2218-5836 [Print] United States
• PMID: 24147269 (Publication Type: Journal Article, Retracted Publication)