Abstract | BACKGROUND: Despite their high effectiveness, progestin-only contraceptives are considered less than ideal by the many women who experience irregular vaginal bleeding when using them. Current treatments to control these bleeding problems are not sufficiently effective. OBJECTIVES: SEARCH METHODS: Literature was identified through database searches, reference lists, organisations and individuals, covering the period until May-June 2012. SELECTION CRITERIA: Trials with random or systematic allocation, testing interventions for the prevention or treatment of bleeding irregularities associated with the use of progestin-only contraceptives were eligible. DATA COLLECTION AND ANALYSIS: Results are expressed as relative risks (RR) with 95% confidence interval (CI) for categorical data and as weighted mean difference (WMD) with 95% CI for continuous data. When we encountered heterogeneity (visual or statistical) we used the random-effects model (quantitative) or did not produce a summary estimate (qualitative). MAIN RESULTS: AUTHORS' CONCLUSIONS: Some women may benefit from the interventions described, particularly with cessation of current bleeding. Several regimens offer promise in regulating bleeding, but findings need to be reproduced in larger trials. The results of this review do not support routine clinical use of any of the regimens included in the trials, particularly for long-term effect.
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Authors | Hany Abdel-Aleem, Catherine d'Arcangues, Kirsten M Vogelsong, Mary Lyn Gaffield, A Metin Gülmezoglu |
Journal | The Cochrane database of systematic reviews
(Cochrane Database Syst Rev)
Issue 10
Pg. CD003449
(Oct 21 2013)
ISSN: 1469-493X [Electronic] England |
PMID | 24146298
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Review, Systematic Review)
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Chemical References |
- Contraceptive Agents, Female
- Contraceptives, Oral, Synthetic
- Delayed-Action Preparations
- Drug Combinations
- Progestins
- Levonorgestrel
- Medroxyprogesterone Acetate
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Topics |
- Contraceptive Agents, Female
(adverse effects, therapeutic use)
- Contraceptives, Oral, Synthetic
(therapeutic use)
- Delayed-Action Preparations
(therapeutic use)
- Drug Combinations
- Female
- Humans
- Levonorgestrel
(adverse effects)
- Medroxyprogesterone Acetate
(therapeutic use)
- Menstruation Disturbances
(chemically induced, drug therapy)
- Progestins
(adverse effects)
- Randomized Controlled Trials as Topic
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