Abstract | OBJECTIVES: DESIGN: Prospective experimental study. SETTING: University laboratory. SUBJECTS: Adult male C57BL/6 mice. INTERVENTIONS: Mice were challenged with lipopolysaccharide (4 or 20 mg/kg, i.p.) to induce endotoxemia with and without recombinant human annexin A5 treatment (5 or 10 μg/kg, i.v.). Cytokine expression and cardiac function were assessed, and animal survival was monitored. MEASUREMENTS AND MAIN RESULTS: CONCLUSIONS:
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Authors | Paul Arnold, Xiangru Lu, Fatemeh Amirahmadi, Katharina Brandl, J Malcolm O Arnold, Qingping Feng |
Journal | Critical care medicine
(Crit Care Med)
Vol. 42
Issue 1
Pg. e32-41
(Jan 2014)
ISSN: 1530-0293 [Electronic] United States |
PMID | 24145837
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Annexin A5
- Interleukin-1beta
- Lipopolysaccharides
- Ly96 protein, mouse
- Lymphocyte Antigen 96
- NF-kappa B
- Recombinant Proteins
- Tlr4 protein, mouse
- Toll-Like Receptor 4
- Tumor Necrosis Factor-alpha
- Mitogen-Activated Protein Kinases
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Topics |
- Animals
- Annexin A5
(pharmacology)
- Dose-Response Relationship, Drug
- Endotoxemia
(drug therapy, mortality, physiopathology)
- Heart
(drug effects, physiopathology)
- Humans
- Inflammation
(physiopathology, prevention & control)
- Interleukin-1beta
(blood, physiology)
- Lipopolysaccharides
(pharmacology)
- Lymphocyte Antigen 96
(physiology)
- Male
- Mice
- Mice, Inbred C57BL
- Mitogen-Activated Protein Kinases
(antagonists & inhibitors, physiology)
- NF-kappa B
(antagonists & inhibitors, physiology)
- Recombinant Proteins
(pharmacology)
- Toll-Like Receptor 4
(physiology)
- Tumor Necrosis Factor-alpha
(biosynthesis, blood, physiology)
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